Increased α1-adrenoreceptor activity is required to sustain blood pressure in female rats under food restriction

Life Sciences
Aline Arlindo de SouzaDeoclecio Alves Chianca

Abstract

We evaluated the effect of food restriction (FR) on the various reflexes involved in short term cardiovascular regulation; we also evaluated the contribution of the sympathetic nervous systemand of the plasmatic nitric oxide (NO) in the development of the counterregulatory cardiovascular changes triggered by FR. Female rats were subjected to FR for 14 days, and after this period biochemical measurements of biochemical parameters were performed. For physiological tests, animals were anaesthetised, and a catheter was inserted into the femoral artery and vein for the acquisition of blood pressure and heart hate, and drug infusion, respectively.We then tested the Bezold–Jarisch reflex, the baroreflex and chemoreflex and the effect of the infusion of adrenergic receptor antagonists in control and food restricted animals. The rats subjected to severe FR presented biochemical changes characteristic of malnutrition with a great catabolic state. FR also led to hypotension and bradycardia besides reducing the plasmatic concentration of NO. Moreover, activation of the Bezold–Jarisch reflex induced a more pronounced hypotensive response in animals subjected to FR. Intravenous infusion of a α1-adrenoreceptor antagonist induced a greater hyp...Continue Reading

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Citations

Sep 26, 2019·Anais Da Academia Brasileira De Ciências·Zhiming ShuChaobin Liu
Jan 12, 2020·Physiological Reports·Aline Maria Arlindo De SouzaRodrigo C A De Menezes

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