Increased 18F-FDG Uptake in Lhermitte-Duclos Disease With Cowden Syndrome Revealed by PET-MRI

Clinical Nuclear Medicine
Eve PiekarskiAurélie Kas

Abstract

A 62-year-old woman, with the history of breast and colorectal cancer, presented intermittent diplopia. A cerebellar lesion was revealed by F-FDG PET-MRI without post-gadolinium enhancement, but with increased perfusion and strong F-FDG uptake. The diagnosis of Cowden syndrome with PTEN gene mutation, linked to higher risk of neoplasia and occurrence of hamartomatous lesions characteristic of the Lhermitte-Duclos disease (LDD), was confirmed by genetic investigation.

References

Sep 24, 2004·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Madakasira V PadmaJoseph C Mantil
Mar 3, 2007·Journal of Neuro-oncology·Toshio NakagawaKan Takeda
Dec 22, 2007·Clinical Nuclear Medicine·Kazumasa HayasakaMasahiko Bundoh
Feb 6, 2013·Neurology·Guangquan WeiTianyun Li

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