Increased AAI mode pacing threshold after termination of atrial fibrillation by acute administration of disopyramide phosphate

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Ryuko AnzawaSeibu Mochizuki

Abstract

We studied changes in atrial pacing threshold after termination of atrial fibrillation (AF) by acute administration of disopyramide phosphate (DP) to elucidate the suitable setting for atrial pacing output before AF termination. Four patients with sick sinus syndrome implanted with AAI mode pacemakers were examined. Disopyramide phosphate (2 mg/kg body weight) was injected intravenously for termination of a total of eight AF episodes. The maximal pacing threshold after AF termination (5.2+/-0.8 V at 0.45 ms) was significantly higher than that at baseline (1.3+/-0.2 V at 0.45 ms; P<0.01) and the average increment was 433+/-68%. During a period free from AF, an acute administration of DP did not increase the atrial pacing threshold and serum disopyramide levels were not toxic. The increased atrial pacing threshold observed after AF termination cannot be explained by the action of DP alone. However, our results suggest that atrial pacing output should be set at the maximum value before DP is administered to induce AF termination in patients with AAI pacemaker-dependent bradyarrhythmias.

References

May 6, 1978·Lancet·A M HaylerG N Volans
Jul 1, 1976·American Heart Journal·A P Niarchos
Feb 1, 1992·Pacing and Clinical Electrophysiology : PACE·L BianconiG Altamura
Feb 1, 1992·European Heart Journal·J SorianoM E Josephson
Apr 1, 1990·Pacing and Clinical Electrophysiology : PACE·N Montefoschi, R Boccadamo
May 1, 1980·Pacing and Clinical Electrophysiology : PACE·W Irnich
Sep 1, 1983·Pacing and Clinical Electrophysiology : PACE·K J HellestrandA J Camm
Apr 1, 1980·The American Journal of Cardiology·J S CamardoM E Josephson
Jul 31, 2001·Pacing and Clinical Electrophysiology : PACE·D AntonelliT Rosenfeld
Mar 17, 2004·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christiane WallerHeiner Langenfeld
May 20, 2004·Journal of Cardiovascular Electrophysiology·Merritt H RaittJohn H McAnulty
Jun 25, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Ryuko AnzawaSeibu Mochizuki

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