PMID: 7328184Dec 1, 1981

Increased absolute calcium binding to albumin in hypoalbuminaemia

Journal of Clinical Pathology
A Besarab, J F Caro

Abstract

The amount of calcium bound to protein was measured in 30 patients with differing diseases and varying degrees of hypoalbuminaemia. Total serum calcium increased directly with both serum albumin and ultrafilterable calcium concentrations. The estimated amount of calcium bound per gram of albumin varied inversely with the albumin concentration, decreasing from 2.1 to 1.0 mg calcium/g albumin as albumin concentration increased from 1.7 to 3.1 g/dl. Circulating parathyroid hormone (PTH) concentrations varied inversely with measured ultrafilterable calcium concentrations. The frequency of raised PTH concentrations decreased as serum albumin increased. Use of a conventional correction factor for albumin binding (0.88 mg calcium bound per gram of albumin) to calculate corrected total calcium led to major errors in estimating ultrafilterable calcium in these patients. The PTH concentrations in turn correlated with the degree of deviation between estimated and measured ultrafilterable calcium concentrations. Ionised calcium was low in seven of ten additional hypoalbuminaemic patients studied whereas correction of total calcium for albumin indicated normocalcaemia in all. Thus correction of total calcium in patients with hypoalbuminaemi...Continue Reading

References

Mar 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C E LemeF P Cesar
Jun 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·C E Leme, H B Silva
Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J H LadensonJ C Boyd
Dec 13, 1975·British Medical Journal·R W PainB M Duncan
Jun 1, 1973·Metabolism: Clinical and Experimental·H BusdanS Locke
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Nov 23, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·F M OlthuisJ B Soons
Jul 6, 1971·Annals of the New York Academy of Sciences·L LundF Sjöqvist
Dec 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·D H Orrell
Dec 1, 1981·Journal of Clinical Pathology·A BesarabJ W Swanson
Aug 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·C W CARR
Apr 1, 1963·The Journal of Clinical Investigation·M WALSERJ W DUCKETT

Citations

Jul 1, 1992·Archives of Gerontology and Geriatrics·A Sorva
Apr 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Arsh JainAndrew House
May 25, 2010·Seminars in Dialysis·A Ross MortonRachel M Holden
Aug 4, 2005·Journal of Endocrinological Investigation·V CarnevaleA Varriale
Jun 9, 2012·Molecular Immunology·Karolina A MajorekWladek Minor
May 1, 1988·Annals of Clinical Biochemistry·T A Gray, C R Paterson
Dec 30, 2020·Journal of Clinical Medicine·Massimo CirilloLicia Iacoviello

Related Concepts

Calcium
Hypocalcemia
Parathyroid Hormone Peptide (1-34)
Plasma Protein Binding Capacity
Plasma Albumin
Ultrafiltration

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
G D Ryan, J R Masarei
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Tomohito GohdaYasuhiko Tomino
© 2021 Meta ULC. All rights reserved