PMID: 3770312Dec 1, 1986Paper

Increased accumulation of sorbitol in offspring of manifest diabetic rats

Diabetes
U J ErikssonS E Brolin

Abstract

The effects of maternal diabetes on somatic development and activity of the polyol pathway were investigated during early and late gestation in a rat model for diabetic pregnancy. We studied embryo-fetal growth, mortality, and malformation rate in the offspring of nondiabetic rats and in the offspring of diabetic rats either treated with an aldose reductase inhibitor during gestation or left untreated. The numbers of embryo-fetal resorptions and malformations were significantly increased in the diabetic groups compared with the controls despite maternal treatment with the aldose reductase inhibitor. The sorbitol content of embryos and membranes from the diabetic rats in early gestation was increased 3-5 times over the control values. Similarly, elevated sorbitol levels were observed in the fetal livers and placentas of the diabetic rats in late gestation. Administration of the aldose reductase inhibitor to the pregnant diabetic rats normalized the sorbitol levels in the embryos and their membranes, whereas the sorbitol contents of the fetal livers and placentas were significantly lowered but not completely corrected. Furthermore, in the diabetic groups, no differences in sorbitol levels could be demonstrated between malformed a...Continue Reading

Citations

May 9, 2012·Metallomics : Integrated Biometal Science·Phillip A WilmarthJason L Burkhead
Jul 1, 2014·BioMed Research International·D C DamascenoM V C Rudge
Apr 1, 1995·Diabetes/metabolism Reviews·U J Eriksson
Mar 5, 1998·Teratology·J Cederberg, U J Eriksson
Jul 1, 1993·Journal of Diabetes and Its Complications·L Baker, R Piddington
Mar 1, 2012·American Journal of Physiology. Endocrinology and Metabolism·A EjdesjöU J Eriksson
Dec 1, 1992·Asia-Oceania Journal of Obstetrics and Gynaecology·T KataseM Yakushiji
Nov 30, 2000·Upsala Journal of Medical Sciences·U J ErikssonP Wentzel
Mar 15, 2019·Metabolomics : Official Journal of the Metabolomic Society·Gaurav V SarodeValentina Medici
Aug 14, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sheller Zabihi, Mary R Loeken
Sep 24, 2020·Expert Opinion on Drug Metabolism & Toxicology·Fabio FacchinettiUNKNOWN Experts Group on Inositol in Basic and Clinical Research
Sep 19, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Margaret P AdamJohn M Graham
Dec 2, 2010·American Journal of Physiology. Endocrinology and Metabolism·A EjdesjöU J Eriksson

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