Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease

Circulation
F DietV J Dzau

Abstract

Angiotensin may play a pathophysiological role in experimental and human cardiovascular disease. Clinical studies have shown that ACE inhibitors reduce mortality, recurrent myocardial infarction, and ischemic events in patients with left ventricular dysfunction. Animal studies suggest that tissue ACE, particularly within blood vessels, may be an important target. To study tissue ACE in human coronary artery disease and to identify potential mechanisms of ACE inhibitor action, we examined ACE expression immunohistochemically in nonatherosclerotic and diseased human coronary arteries. In nonatherosclerotic arteries, ACE immunoreactivity was found in luminal and adventitial vasa vasorum endothelium. In early- and intermediate-stage atherosclerotic lesions, ACE was detected prominently in regions of fat-laden macrophages and in association with T lymphocytes. In advanced lesions, ACE immunoreactivity was also localized to the endothelium of the microvasculature throughout the plaques. Immunoreactive angiotensin II was also detected in these areas. ACE expression in macrophages was further examined by in vitro experiments with a monocytoid cell line. ACE activity was induced threefold after differentiation of the cells into macropha...Continue Reading

References

Mar 12, 1976·Science·P R CaldwellR L Soffer
Jul 1, 1992·Journal of Hypertension·F M RogersonF A Mendelsohn
Jan 15, 1992·Biochemical and Biophysical Research Communications·R D FarhyA G Scicli
Jan 1, 1990·Journal of Cardiovascular Pharmacology·G Aberg, P Ferrer
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Oct 1, 1991·Hypertension·W OsterriederH R Baumgartner
Jun 27, 1989·Biochemistry·M R Ehlers, J F Riordan
Jun 27, 1994·FEBS Letters·A W HahnT J Resink
Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S M DanilovR V Lacis
Apr 1, 1993·The Journal of Clinical Investigation·J R SchuhE H Blaine

❮ Previous
Next ❯

Citations

May 6, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian WernerMichael Böhm
Mar 23, 2010·Pflügers Archiv : European journal of physiology·Ulrich Förstermann
Dec 21, 2000·Current Atherosclerosis Reports·R Kraemer
Apr 29, 2010·Current Atherosclerosis Reports·Alan DaughertyLisa A Cassis
Jul 16, 2008·Current Hypertension Reports·Anu Lala, Mary Ann McLaughlin
Jul 16, 2002·Current Hypertension Reports·Sumeska Thavarajah, George A Mansoor
Mar 31, 2004·Molecular Aspects of Medicine·Elena M V de CavanaghCesar G Fraga
Nov 6, 2001·The American Journal of Cardiology·V J DzauUNKNOWN Working Group on Tissue Angiotensin-converting enzyme, International Society of Cardiovascular Pharmacotherapy
Apr 27, 2000·Atherosclerosis·R MetzgerF E Franke
Jul 17, 1998·Life Sciences·S Keidar
Oct 18, 2000·Regulatory Peptides·K M Schmidt-OttM I Phillips
Jul 14, 2001·Journal of the American College of Cardiology·G G Neri SerneriP A Modesti
Oct 5, 2001·Journal of the American College of Cardiology·A PrasadA A Quyyumi
May 15, 1998·Journal of the American College of Cardiology·M J MullenJ E Deanfield
Oct 12, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M RichterH G Olbrich
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Feb 23, 2012·Molecular Pharmaceutics·Tanja OuimetSébastien Ballet
Dec 5, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kanta FujimiHidenori Urata
Apr 23, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Eberhard SchulzThomas Münzel
Sep 28, 2006·Nature Clinical Practice. Nephrology·Nosratola D Vaziri, Bernardo Rodríguez-Iturbe
Oct 3, 1999·Kidney International·R MetzgerF E Franke
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lijun GengSiv F E Nilsson
Apr 11, 2003·Diabetes Technology & Therapeutics·David W Moskowitz
Feb 8, 2003·Antioxidants & Redox Signaling·Ibrahim R HannaKathy K Griendling
Mar 7, 2008·Antioxidants & Redox Signaling·Eberhard SchulzThomas Münzel
Mar 20, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karsten GroteBernhard Schieffer
Feb 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christof UlrichMatthias Girndt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.