PMID: 8594918Dec 1, 1995Paper

Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation

The American Journal of Physiology
Louis J Dell'ItaliaSuzanne Oparil

Abstract

The current study was designed to test the hypothesis that intracardiac angiotensin-converting enzyme (ACE) activity, chymase-like activity, and angiotensin (ANG) peptide levels are increased and are positively related to wall stress estimates in response to the chronic low pressure volume overload of mitral regurgitation produced by percutaneous chordal rupture in the dog. Chronic mitral regurgitation (MR) resulted in an increase in left ventricular (LV) end-diastolic volume [59 +/- 11 (SD) to 103 +/- 32 ml, P < 0.001], LV mass (96 +/- 17 to 114 +/- 23 g, P < 0.001), and a decrease in the LV mass-to-end-diastolic volume ratio (1.64 +/- 0.22 to 1.16 +/- 0.23 g/ml, P < 0.001) measured by magnetic resonance imaging. In vitro studies of heart tissue extracts demonstrated that the majority of ANG II-forming activity was from chymase-like activity rather than from ACE activity in five normal (83.5 +/- 7.5 vs. 6.04 +/- 5.2%) and seven MR hearts (86 +/- 3.9 vs. 2.6 +/- 1.7%). ACE activity (1.22 +/- 0.22 vs. 3.55 +/- 0.62 mU/g, P < 0.05) and chymase-like activity (9.42 +/- 4.64 vs. 20.60 +/- 8.41 nmol.g-1.min-1, P < 0.05) were increased in MR compared with normal hearts. ACE activity correlated with the LV mass-to-volume ratio (r = -0....Continue Reading

Citations

May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Chang WeiLouis J Dell'Italia
Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison E GirasoleJean C Hardwick
Jul 26, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hyemoon ChungMasafumi Kitakaze
Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y NagatomoF G Spinale
Jul 3, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Norihito MoniwaCarlos M Ferrario
Mar 29, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Chang WeiLouis J Dell'Italia
Oct 3, 2002·Journal of Hypertension·Lan-Ying ChenLi-Sheng Liu

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