Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression

Archives of General Psychiatry
E A NofzingerD J Kupfer

Abstract

Depression is associated with sleep disturbances, including alterations in rapid eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that REM sleep activates limbic and anterior paralimbic cortex and that depressed patients demonstrate increases in electroencephalographic sleep measures of REM, we hypothesized greater activation of these structures during waking to REM sleep in depressed patients. Subjects completed electroencephalographic sleep and regional cerebral glucose metabolism assessments during both waking and REM sleep using [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography. Patients and healthy subjects recruited from the general community to participate in a research study of depression at an academic medical center. Patients Twenty-four unmedicated patients who met the Structured Clinical Interview for DSM-IV criteria for current major depression and who had a score of 15 or higher on a 17-item Hamilton Rating Scale for Depression; 14 medically healthy subjects of comparable age and sex who were free of mental disorders. Electroencephalographic sleep, semiquantitative and relative regional cerebral metabolism during waking and REM sleep. Depressed patients showed greater...Continue Reading

Citations

Mar 9, 2006·Current Neurology and Neuroscience Reports·Eric A Nofzinger
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Dec 17, 2009·Der Nervenarzt·J P DoerrU Voderholzer
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