Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome

Immunobiology
Dragana Popovic-KuzmanovicVladimir Trajkovic

Abstract

The aim of the study was to investigate serum concentrations of interleukin (IL)-17 and IL-17-inducing cytokines IL-23 and transforming growth factor (TGF)-β, as well as IL-17 single nucleotide polymorphism (SNP) rs2275913 in patients with primary antiphospholipid syndrome (PAPS). We studied fifty patients with PAPS and fifty age- and sex-matched healthy controls. The cytokine levels were measured by ELISA, while the rs2275913 SNP located in promoter region of IL-17 gene was genotyped using real-time PCR. The significantly higher levels of IL-17 (p=0.002), IL-23 (p<0.001) and TGF-β (p=0.042) were found in PAPS patients (median 13.1, 9.4, and 125.6 pg/ml, respectively) compared to the control group (6.8, 4.9 and 44.4 pg/ml). There was a significant positive correlation between concentrations of IL-17 and IL-23 (r=0.540, p<0.001), but not between those of IL-17 and TGF-β. No statistically significant differences were observed in the distribution of genotypes and alleles of the IL-17 rs2275913 variants in patients with PAPS compared to healthy subjects. The blood concentrations of IL-17 did not differ in subjects with different rs2275913 genotypes or patients with or without antiphospholipid antibodies. Finally, a trend toward hig...Continue Reading

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Citations

Sep 5, 2013·Autoimmunity Reviews·Henrique Luiz StaubMoisés Evandro Bauer
Sep 1, 2015·Autoimmunity Reviews·Lucas L van den HoogenRonald H W M Derksen
Mar 22, 2019·Frontiers in Immunology·Lorena Álvarez-RodríguezMarcos López-Hoyos
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May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Chien LinKuo-Tung Tang

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