Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition

Cardiovascular Research
Barbara Kutryb-ZajacRyszard T Smolenski

Abstract

Extracellular nucleotides and adenosine that are formed or degraded by membrane-bound ecto-enzymes could affect atherosclerosis by regulating the inflammation and thrombosis. This study aimed to evaluate a relation between ecto-enzymes that convert extracellular adenosine triphosphate to adenine dinucleotide phosphate, adenosine monophosphate, adenosine, and inosine on the surface of the vessel wall with the severity or progression of experimental and clinical atherosclerosis. Furthermore, we tested whether the inhibition of adenosine deaminase will block the development of experimental atherosclerosis. Vascular activities of ecto-nucleoside triphosphate diphosphohydrolase 1, ecto-5'-nucleotidase, and ecto-adenosine deaminase (eADA) were measured in aortas of apolipoprotein E-/- low density lipoprotein receptor (ApoE-/-LDLR-/-) and wild-type mice as well as in human aortas. Plaques were analysed in the entire aorta, aortic root, and brachiocephalic artery by Oil-Red O and Orcein Martius Scarlet Blue staining and vascular accumulation of macrophages. The cellular location of ecto-enzymes was analysed by immunofluorescence. The effect of eADA inhibition on atherosclerosis progression was studied by a 2-month deoxycoformycin treat...Continue Reading

References

Sep 1, 1986·The Journal of Clinical Investigation·B N CronsteinR Hirschhorn
Jan 1, 1980·Cancer Chemotherapy and Pharmacology·R P Agarwal
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S IshibashiM S Brown
Jan 6, 1997·The Journal of Experimental Medicine·S C RobsonF H Bach
Jul 1, 1997·Progress in Neurobiology·R FrancoC Lluis
May 30, 1998·Clinical and Experimental Hypertension : CHE·S P TofovicE K Jackson
Oct 12, 2001·Annals of the New York Academy of Sciences·R Kurzrock
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Geoffrey Burnstock
May 28, 2002·Molecular and Cellular Biochemistry·Kameljit KalsiRyszard T Smolenski
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Elliott S CohenSteven M Hollenberg
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·R PachecoR Franco
Sep 20, 2005·Biochemical and Biophysical Research Communications·Guixiang ZhaoPenny M Kris-Etherton
Jan 30, 2007·Indian Journal of Medical Sciences·Vishwas ChavanN D Karnik
Jul 3, 2007·British Journal of Pharmacology·S A LévesqueJ Sévigny
Mar 15, 2008·Inflammatory Bowel Diseases·Jeffrey B BrownTerrence A Barrett
Apr 12, 2008·Purinergic Signalling·Norbert Sträter
Sep 16, 2008·European Journal of Pharmacology·Stina M JohanssonBertil B Fredholm
Oct 9, 2008·Angiology·Edward KowalczykMaciej Banach
Nov 20, 2008·Current Protocols in Immunology·Xia ZhangDavid M Mosser
Jan 15, 2009·Journal of Vascular Research·John H BeattieMargaret-Jane Gordon
Jul 31, 2009·Cardiovascular Research·Gilles KauffensteinJean Sévigny
Aug 8, 2009·The British Journal of Nutrition·Shu WangAlice H Lichtenstein
Aug 1, 2008·Current Cardiology Reviews·Tieying HouAllan R Brasier
Oct 21, 2010·Journal of Leukocyte Biology·José M Martinez-NavioRafael Franco
Oct 1, 2011·Cardiovascular Research·Anja BuchheiserJürgen Schrader
Mar 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Allison B Reiss, Bruce N Cronstein
Jan 16, 2013·Annals of the Royal College of Surgeons of England·Z KhalpeyR T Smolenski
Jun 17, 2014·Medicinal Research Reviews·Antoni CortésVicent Casadó

❮ Previous
Next ❯

Citations

Oct 7, 2018·Journal of Cellular and Molecular Medicine·Barbara Kutryb-ZajacRyszard T Smolenski
Dec 28, 2018·Nucleosides, Nucleotides & Nucleic Acids·Marta ToczekRyszard T Smolenski
Dec 28, 2018·Nucleosides, Nucleotides & Nucleic Acids·Barbara Kutryb-ZajacRyszard T Smolenski
Aug 6, 2019·Journal of the American Heart Association·Trevor SimardBenjamin Hibbert
Nov 14, 2019·Current Pharmaceutical Design·Arduino A MangoniCiriaco Carru
Jun 11, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vanessa Plasse RamosRejane Giacomelli Tavares
Sep 17, 2020·Hormones : International Journal of Endocrinology and Metabolism·Areta HebanowskaAlicja Braczko
May 31, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Barbara Kutryb-ZajacRyszard T Smolenski
Mar 3, 2018·Frontiers in Pharmacology·Estefanía MorenoVicent Casadó
Sep 15, 2019·International Journal of Biological Macromolecules·S BagheriT Haertlé
Mar 3, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ming YuJi Zhang
Mar 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J K AkintundeL O Ajisafe
May 1, 2021·International Journal of Molecular Sciences·Barbara Kutryb-ZajacRyszard T Smolenski
Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara Kutryb-ZajacRyszard T Smolenski
Jun 19, 2021·Journal of Cellular and Molecular Medicine·Patrycja JablonskaEwa M Slominska

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.