Increased acylation-stimulating protein, C-reactive protein, and lipid levels in young women with polycystic ovary syndrome

Fertility and Sterility
Yuwen WuK Cianflone

Abstract

To evaluate potential changes that are independent of body size in the lipogenic adipokine acylation-stimulating protein (ASP), complement C3 (ASP precursor), and C-reactive protein (CRP) in subjects with polycystic ovary syndrome (PCOS). Cross-sectional analysis. Endocrine clinic in China. Thirty-four women with PCOS and 41 age- and body mass index (BMI)-matched controls were recruited. Fasting blood samples were collected. Plasma glucose, insulin, lipids, ASP, C3, CRP, and homeostasis model assessment of insulin resistance were measured. Plasma ASP, CRP, insulin, cholesterol, and nonesterified fatty acids were increased significantly in women with PCOS compared with in controls. Although each of these parameters also was statistically significantly correlated directly with BMI, the association with PCOS status was independent of BMI, with increased plasma values at all levels of BMI. In control subjects, CRP and C3 correlated with glucose and triglyceride, only CRP correlated with nonesterified fatty acids and cholesterol, and ASP correlated with triglyceride (again, all correlations were significant), whereas in subjects with PCOS, several of these correlations were lost, as a result of consistently higher levels of CRP and ...Continue Reading

References

May 1, 1989·The Journal of Surgical Research·M J WalshR A Forse
Sep 1, 1993·The Journal of Clinical Investigation·A BaldoK Cianflone
Nov 21, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J A CharlesworthT Tzilopoulos
Apr 17, 1999·Metabolism: Clinical and Experimental·F GonzalezP Dandona
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·S BhakdiM Hemmes
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·E O TalbottL H Kuller
Feb 13, 2001·Annual Review of Medicine·A Dunaif, A Thomas
Mar 14, 2001·Circulation·G ParadisiA D Baron
Jan 5, 2002·The American Journal of Medicine·R S LegroA Dunaif
Feb 28, 2002·Cardiovascular Research·Tomi S Mikkola, Thomas B Clarkson
Jun 25, 2002·Human Reproduction Update·Robert A Wild
Nov 26, 2002·Obstetrical & Gynecological Survey·Joop S E LavenBart C J M Fauser
Jan 24, 2003·The Journal of Biological Chemistry·David KalantPeter N Monk
Jan 25, 2003·Biochimica Et Biophysica Acta·Katherine CianfloneLan Ying Chen
Mar 29, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K TamakoshiH Toyoshima
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Rose C ChristianLorraine A Fitzpatrick
Jun 12, 2003·Obstetrics and Gynecology·Giovanni AmatoAlfredo Izzo
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Donald P KotlerJeanine B Albu
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Miriam E SilfenSharon E Oberfield
Oct 18, 2003·Journal of Lipid Research·Katherine CianfloneAllan Sniderman
Nov 19, 2003·The Korean Journal of Internal Medicine·Woo Kon JeongJung Chaee Kang
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Mar 24, 2004·Fertility and Sterility·Sylvia Kirchengast, Johannes Huber
Mar 25, 2005·The New England Journal of Medicine·David A Ehrmann
Jul 28, 2005·The Journal of Clinical Endocrinology and Metabolism·C MeyerH J Teede
Nov 23, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y YangK Cianflone

❮ Previous
Next ❯

Citations

Jun 2, 2011·Human Reproduction Update·Konstantinos A ToulisBasil C Tarlatzis
Feb 25, 2009·Journal of Lipid Research·Sabina PaglialungaKatherine Cianflone
Jun 15, 2011·Wilderness & Environmental Medicine·Jessica D SmithMartin Noël
Dec 21, 2010·Fertility and Sterility·Héctor F Escobar-MorrealeFrank González
Feb 26, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J SalehK Cianflone
Jan 14, 2010·Journal of Cellular Biochemistry·Ying GaoKatherine Cianflone
Nov 3, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Estela Rey-RoldanManuel Patricio Nolting
Mar 7, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Michelle L SnyderEvelyn O Talbott
Mar 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ozgul Muneyyirci-DelaleVijaya L Nacharaju
Nov 26, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevtap KilicSertac Batioglu
Jan 29, 2010·Clinical Endocrinology·R W J LeunissenA C S Hokken-Koelega
Oct 9, 2009·Expert Review of Proteomics·William U AtiomoRobert Layfield
Sep 15, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sedighe MoradiScott Reza Jafarian Kerman
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christian RoyKatherine Cianflone
Mar 17, 2017·Journal of Assisted Reproduction and Genetics·Yue LvJinlong Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.