Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury

Malaria Journal
James A ChurchBritta C Urban

Abstract

Children with severe malaria are at increased risk of invasive bacterial disease particularly infection with enteric gram-negative organisms. These organisms are likely to originate from the gut, however, how and why they breach the intestinal interface in the context of malaria infection remains unclear. One explanation is that accumulation of infected red blood cells (iRBCs) in the intestinal microvasculature contributes to tissue damage and subsequent microbial translocation which can be addressed through investigation of the impact of cytoadhesion in patients with malaria and intestinal damage. Using a static adhesion assay, cytoadhesion of iRBCs was quantified in 48 children with malaria to recombinant proteins constitutively expressed on endothelial cell surfaces. Cytoadhesive phenotypes between children with and without biochemical evidence of intestinal damage [defined as endotoxemia or elevated plasma intestinal fatty acid binding protein (I-FABP)] was compared. The majority of parasites demonstrated binding to the endothelial receptors CD36 and to a lesser extent to ICAM-1. Reduced adhesion to CD36 but not adhesion to ICAM-1 or rosetting was associated with malarial anaemia (p = 0.004). Increased adhesion of iRBCs to ...Continue Reading

References

Feb 1, 1991·The American Journal of Tropical Medicine and Hygiene·E PongponratnM Aikawa
Oct 1, 1995·Seminars in Immunology·S K Shaw, M B Brenner
Mar 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P WilairatanaS Looareesuwan
Nov 5, 1997·The American Journal of Tropical Medicine and Hygiene·C NewboldK Marsh
Sep 25, 1999·The American Journal of Tropical Medicine and Hygiene·S J RogersonM E Molyneux
Jul 10, 2004·The Journal of Infectious Diseases·John C MarshallUNKNOWN MEDIC study
Nov 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen GoebelChristopher G Kevil
Jun 3, 2006·The Journal of Infectious Diseases·Jacqui MontgomeryMalcolm E Molyneux
Jun 17, 2006·The Journal of Infectious Diseases·Karl B SeydelTerrie E Taylor
Oct 19, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jean-Marc Cavaillon, Minou Adib-Conquy
Nov 10, 2007·The American Journal of Clinical Nutrition·Clett ErridgeDavid J Webb
Aug 6, 2008·Critical Care Medicine·Christoph J HemmerEmil C Reisinger
Sep 5, 2009·Critical Care Medicine·Joep P M DerikxDick A van Waardenburg
May 28, 2011·The New England Journal of Medicine·Kathryn MaitlandUNKNOWN FEAST Trial Group
Aug 27, 2011·American Journal of Respiratory and Critical Care Medicine·Nazima PathanJane A Mitchell
Mar 19, 2013·BMC Infectious Diseases·Peter Olupot-OlupotKathryn Maitland
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Holly M BiggsJohn A Crump

❮ Previous
Next ❯

Citations

Jun 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ne Myo AungJosh Hanson
Dec 5, 2019·Tropical Diseases, Travel Medicine and Vaccines·Sergey YegorovRupert Kaul
Feb 3, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ne Myo AungJosh Hanson

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

ISRCTN69856593

Software Mentioned

Pro Analyser
QCapture Pro
Stata
FEAST
Image

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.