Increased adrenomedullin protein content and mRNA expression in human fetal membranes but not placental tissue in pre-eclampsia

Molecular Human Reproduction
A Al-GhafraR G King

Abstract

The relationship between Pre-eclampsia (PE) and placental production of Adrenomedullin (AdM) is not completely understood. This study measured placental and fetal membrane AdM protein concentrations by specific radioimmunoassay and mRNA expression by Northern blot analysis in samples obtained at either term or preterm gestation from women either in labour or not in labour. Samples were obtained from women with normotensive and pre-eclamptic pregnancies. There were significant increases in immunoreactive AdM protein concentration (pg/mg DNA) in choriodecidua and amnion of women with PE compared to normal pregnancy for the preterm not-in-labour group (choriodecidua: control 124 +/- 16, n = 10, PE 361 +/- 35, n = 10; amnion: control 94 +/- 12, n = 10, PE 153 +/- 19, n = 10) and for the term not-in-labour (choriodecidua: control 128 +/- 17, n = 14, PE 459 +/- 51, n = 8; amnion: control 112 +/- 15, n = 14, PE 253 +/- 57, n = 8) and in-labour (choriodecidua: control 531 +/- 74, n = 14, PE 881 +/- 188, n = 8; amnion: control 545 +/- 84, n = 14, PE 1008 +/- 230, n = 8) groups. AdM mRNA relative abundance was greater in preterm, not-in-labour choriodecidual samples in PE, but not in amnion. In addition, this study observed labour-associ...Continue Reading

References

Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Oct 1, 1996·American Journal of Obstetrics and Gynecology·C J MacriF Cuttitta
Feb 1, 1997·Lancet·R Di IorioE V Cosmi
Jan 1, 1997·Current Opinion in Nephrology and Hypertension·K Kitamura, T Eto
Dec 11, 1997·Lancet·T HataK Matsui
Mar 10, 1998·Endocrinology·Y IsumiN Minamino
May 16, 1998·Endocrinology·V A Cameron, A M Fleming
Oct 17, 1998·Hypertension·R Di IorioE V Cosmi
Apr 27, 1999·European Journal of Endocrinology·R Di IorioE V Cosmi
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·S UedaS Miyamoto
Mar 10, 2000·Regulatory Peptides·E MarinoniE V Cosmi
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·H J SinghA Nila
Sep 25, 2001·American Journal of Obstetrics and Gynecology·R Di IorioE V Cosmi
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Vicky A CameronA Mark Richards
Mar 22, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ina KnerrWolfgang Rascher
Aug 24, 2002·Biology of Reproduction·Andrea G WitlinChandrasekhar Yallampalli
Apr 2, 2003·Regulatory Peptides·Romolo Di IorioErmelando V Cosmi
Apr 2, 2003·Regulatory Peptides·Katsuyuki Ando, Toshiro Fujita
Jun 5, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Onder CelikYusuf Turkoz
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·R J GrattonV K M Han
Feb 11, 2004·Circulation·Junsuke KawaiToshiro Fujita

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Citations

Mar 20, 2012·Trends in Endocrinology and Metabolism : TEM·Patricia M Lenhart, Kathleen M Caron
Nov 19, 2010·The Journal of Obstetrics and Gynaecology Research·Ashraf I El-mashadYaser Ismail
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Premila PaivaStephen Tong
Sep 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·William P MarinelloLiping Feng

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