Increased aldosterone levels in a model of type 2 diabetes mellitus

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
S FredersdorfJ Weil

Abstract

Aldosterone is an important mediator of cardiovascular and renal remodeling. Type II diabetes mellitus leads to renal and cardiac end organ damage. We investigated the renin-angiotensin-aldosterone system in a model of type 2 diabetes mellitus with known diabetic nephropathy and cardiac remodeling, the Zucker Diabetic Fatty rat with and without ACE-inhibition (ZDF and ZDF+ACE-I) and its control, the Zucker Lean (ZDL) rat. Male animals were studied from an age of 7-24 weeks. At ages 7, 14, 17, 20, and 23 weeks, urinary excretion of aldosterone-glucuronide and potassium was assessed. ACE-inhibition with ramipril was started orally at week 13 (1 mg/kg/d). At the end of the study rats were sacrificed and plasma aldosterone concentration and plasma renin activity were measured. Aldosterone synthase (CYP11B2) mRNA expression in the adrenals, kidney, heart and adipose tissue was assessed by real-time PCR. Urinary albumin excretion as marker for diabetic nephropathy was measured in metabolic cages and correlated to aldosterone. Plasma aldosterone concentration and aldosterone-glucuronide was significantly elevated in ZDF rats, and significantly reduced by ACE-inhibiton. In contrast, plasma renin activity was significantly reduced in ZD...Continue Reading

Citations

Jul 29, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Markus ReschDierk H Endemann
Jan 17, 2013·Cardiovascular Diabetology·Márta SárközyTamás Csont
Oct 30, 2014·Diabetology & Metabolic Syndrome·Thiago Bruder-NascimentoRita C Tostes
Nov 14, 2012·Life Sciences·Chirag H MandaviaJames R Sowers
Jul 16, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Juliana Almada ColucciDulce Elena Casarini
Nov 15, 2017·Current Opinion in Nephrology and Hypertension·Jessica L FaulknerEric J Belin de Chantemèle
Nov 16, 2019·Diabetes Care·Aneta M GawlikZe'ev Hochberg
Apr 9, 2016·Veterinary World·Tossou Jacques Dougnon, Messanvi Gbeassor

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