Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid

Neuroscience Letters
David BlumR Sadoul

Abstract

Chronic intoxication by 3-nitropropionic acid in the Lewis rat reproduces many features reminiscent of Huntington's disease including behavioural alterations and cortico-striatal degeneration. In particular, in this model, striatal degeneration is accompanied by calpain activation as found in the human disease. The present study was undertaken to determine whether the expression of Alix (apoptosis linked gene-2 interacting protein), a widespread protein involved in neuronal death, would be modified in the striatum and cortex of 3NP-treated rats. The results clearly show that Alix immunoreactivity is increased in the neuronal cell bodies of the lateral striatum, where degeneration is massive. The medial striatum and the cortex that lack neurodegeneration remain only weakly labelled. This is further evidence suggesting an involvement of Alix in the events driving neuronal death.

References

Oct 9, 1999·Progress in Neurobiology·E BrouilletP Hantraye
May 30, 2002·The Journal of Biological Chemistry·Christine Chatellard-CausseRemy Sadoul
Jul 4, 2002·Neuromolecular Medicine·Tamara KiechleRobert J Ferrante
Nov 26, 2002·Biochimica Et Biophysica Acta·Masatoshi MakiHideki Shibata
Apr 25, 2003·Gene Expression Patterns : GEP·Sandrine FrabouletRémy Sadoul
Sep 25, 2003·Cell·Bettina StrackHeinrich G Göttlinger
Oct 23, 2003·Human Molecular Genetics·Zheng-Hong QinMarian DiFiglia
Oct 31, 2003·The Journal of Biological Chemistry·Yaël TrioulierRémy Sadoul

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Citations

Sep 14, 2006·Acta Neuropathologica·Jörg BäurleSabine Frischmuth
Mar 26, 2013·Clinical Proteomics·Abhilash K VenugopalSusarla K Shankar
Dec 16, 2005·Biology of the Cell·Rémy Sadoul
Jun 13, 2006·European Journal of Cell Biology·Sara MatteiLaurence Aubry
May 18, 2010·Biochemical and Biophysical Research Communications·Flavie StrappazzonRémy Sadoul
Mar 23, 2017·Scientific Reports·Marine H LaporteRémy Sadoul
Mar 23, 2012·Experimental Neurobiology·Jin-A Lee, Fen-Biao Gao
Jan 16, 2009·Biochemical Society Transactions·Anne-Laure Mahul-MellierRémy Sadoul
Jan 29, 2021·International Journal of Molecular Sciences·Ryuta InukaiHideki Shibata
Jul 27, 2006·Journal of Cell Science·Greg Odorizzi

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