Abstract
Chronic intoxication by 3-nitropropionic acid in the Lewis rat reproduces many features reminiscent of Huntington's disease including behavioural alterations and cortico-striatal degeneration. In particular, in this model, striatal degeneration is accompanied by calpain activation as found in the human disease. The present study was undertaken to determine whether the expression of Alix (apoptosis linked gene-2 interacting protein), a widespread protein involved in neuronal death, would be modified in the striatum and cortex of 3NP-treated rats. The results clearly show that Alix immunoreactivity is increased in the neuronal cell bodies of the lateral striatum, where degeneration is massive. The medial striatum and the cortex that lack neurodegeneration remain only weakly labelled. This is further evidence suggesting an involvement of Alix in the events driving neuronal death.
References
Jan 26, 1996·Science·P VitoL D'Adamio
Nov 11, 1998·Molecular Cell·A SittlerE E Wanker
Jan 9, 1999·The Journal of Biological Chemistry·P VitoL D'Adamio
Apr 14, 1999·Cell Death and Differentiation·M MissottenR Sadoul
Jun 9, 1999·Biochemistry·K W LoM Zhang
Oct 9, 1999·Progress in Neurobiology·E BrouilletP Hantraye
Jun 1, 2000·Neuroscience·S OuaryE Brouillet
Jun 20, 2000·The Journal of Biological Chemistry·B ChenO Bogler
Jun 21, 2001·Neuroreport·D BlumS N Schiffmann
May 30, 2002·The Journal of Biological Chemistry·Christine Chatellard-CausseRemy Sadoul
Jul 4, 2002·Neuromolecular Medicine·Tamara KiechleRobert J Ferrante
Nov 26, 2002·Biochimica Et Biophysica Acta·Masatoshi MakiHideki Shibata
Apr 25, 2003·Gene Expression Patterns : GEP·Sandrine FrabouletRémy Sadoul
Jul 10, 2003·Lancet Neurology·David BlumSerge N Schiffmann
Jul 16, 2003·The Journal of Biological Chemistry·Keiichi KatohMasatoshi Maki
Aug 15, 2003·The Journal of Biological Chemistry·Nicolas BizatEmmanuel Brouillet
Sep 25, 2003·Cell·Bettina StrackHeinrich G Göttlinger
Oct 23, 2003·Human Molecular Genetics·Zheng-Hong QinMarian DiFiglia
Oct 31, 2003·The Journal of Biological Chemistry·Yaël TrioulierRémy Sadoul
Jan 1, 2004·Neuroscience Letters·David BlumSerge N Schiffmann
Jan 31, 2004·Neuroscience·F J HemmingR Sadoul
Jan 31, 2004·Neurobiology of Disease·Marie Christine GalasDavid Blum
Feb 26, 2004·The Journal of Biological Chemistry·Juliette GafniLisa M Ellerby
Citations
Sep 14, 2006·Acta Neuropathologica·Jörg BäurleSabine Frischmuth
Mar 26, 2013·Clinical Proteomics·Abhilash K VenugopalSusarla K Shankar
Aug 1, 2012·PloS One·Sheila K PiroozniaFelice Elefant
Jan 20, 2016·Journal of Proteomics·Kathleen RolandFrédéric Silvestre
Dec 25, 2012·Aquatic Toxicology·Kathleen RolandFrédéric Silvestre
Apr 14, 2009·Neuroscience·J C KraftM A Johnson
Dec 16, 2005·Biology of the Cell·Rémy Sadoul
Jun 27, 2006·Brain Research·Heather A SkynnerPaul C Guest
Jun 13, 2006·European Journal of Cell Biology·Sara MatteiLaurence Aubry
May 18, 2010·Biochemical and Biophysical Research Communications·Flavie StrappazzonRémy Sadoul
Jan 1, 2015·Cell Discovery·Sheng SunJian Kuang
Mar 23, 2017·Scientific Reports·Marine H LaporteRémy Sadoul
Mar 23, 2012·Experimental Neurobiology·Jin-A Lee, Fen-Biao Gao
May 12, 2019·FEBS Letters·Sharifah SalimPhilip E Chen
Jan 16, 2009·Biochemical Society Transactions·Anne-Laure Mahul-MellierRémy Sadoul
Jan 29, 2021·International Journal of Molecular Sciences·Ryuta InukaiHideki Shibata
Jul 27, 2006·Journal of Cell Science·Greg Odorizzi