Abstract
We aimed to evaluate all-cause mortality of middle-aged and elderly subjects diagnosed with dementia and treated with psychotropic drugs as compared with controls subjects. Using data from the Danish National Patient Registry, n=26,821 adults with a diagnosis of dementia were included. They were compared with 44,286 control subjects with a minimum follow-up of four years and matched on age, gender, marital status, and community location. Information about psychotropic medication use (benzodiazepines, antidepressants, antipsychotics) was obtained from the Danish Medicinal Product Statistics. All-cause mortality was higher in patients with dementia as compared to control subjects. Mortality hazard ratios were increased for subjects prescribed serotonergic antidepressant drugs (respectively, HR=1.355 (SD=0.023), P=0.001 in patients; HR=1.808 (0.033), P<0.001 in controls), tricyclic antidepressants (HR=1.004 (0.046), P=0.925; HR=1.406 (0.061), P<0.001), benzodiazepines (HR=1.131 (0.039), P=0.060); HR=1.362 (0.028), P<0.001), benzodiazepine-like drugs (HR=1.108 (0.031), P=0.078; HR=1.564 (0.037, P<0.001), first-generation antipsychotics (HR=1.183 (0.074), P=0.022; HR=2.026 (0.114), P<0.001), and second-generation antipsychotics (HR=...Continue Reading
References
Aug 1, 1989·American Journal of Public Health·C Allgulander
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
May 16, 1998·Biological Psychiatry·D F KripkeL Garfinkel
Mar 9, 1999·Journal of Cardiothoracic and Vascular Anesthesia·N CreggE D Wigle
Jan 26, 2000·Journal of Sleep Research·A SchuldT Pollmächer
Mar 3, 2001·Scandinavian Journal of Public Health·J MerloA Melander
Jul 13, 2001·Journal of Psychopharmacology·L V WiltonS A Shakir
May 7, 2002·Journal of Toxicology. Clinical Toxicology·Papa N GueyeFrédéric J Baud
Jun 11, 2003·Neurology·S A FactorUNKNOWN Parkinson Study Group
Oct 20, 2005·JAMA : the Journal of the American Medical Association·Lon S SchneiderPhilip Insel
Dec 2, 2005·The New England Journal of Medicine·Philip S WangM Alan Brookhart
Dec 15, 2005·Neuroepidemiology·R S WilsonD A Evans
Jul 20, 2006·The Journal of Clinical Psychiatry·Ludmila A KryzhanovskayaPatrizia A Cavazzoni
Sep 14, 2007·Kidney International·W C WinkelmayerP S Wang
Sep 28, 2007·The American Journal of Psychiatry·Helen C KalesFrederic C Blow
Apr 4, 2008·PLoS Medicine·Clive BallardUNKNOWN Investigators DART AD
Mar 10, 2009·Sleep Medicine·Daniel F Kripke
Mar 10, 2009·Sleep Medicine·Lena MallonJerker Hetta
Mar 24, 2009·Current Neuropharmacology·Rosa LiperotiAndrea Corsonello
Jun 24, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Chi-Shin WuKeh-Ming Lin
Jul 21, 2009·Journal of Psychosomatic Research·Jason C OngRachel Manber
Jul 6, 2010·Sleep Medicine·Xuân-Lan NguyênBernard Fleury
May 17, 2011·The American Journal of Psychiatry·Cheryl L P VigenLon S Schneider
Sep 17, 2011·European Heart Journal·Jussi HonkolaHeikki V Huikuri
Dec 24, 2011·The American Journal of Psychiatry·Helen C KalesFrederic C Blow
Jan 26, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Connie MarrasPaula A Rochon
Mar 1, 2012·BMJ Open·Daniel F KripkeLawrence E Kline
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Sachin BhaleraoHelen C Kales
Jun 12, 2012·BMC Medical Research Methodology·Nicole PrattPhilip Ryan
Sep 15, 2012·BMJ Open·Arthur Hartz, John Jacob Ross
Oct 30, 2012·Journal of Neurology·Poul JennumJakob Kjellberg
Oct 31, 2012·Acta Psychiatrica Scandinavica·Lone BaandrupBirte Glenthoj
Dec 15, 2012·Spine·Poul JennumTom Bendix
Mar 5, 2013·The Medical Journal of Australia·Angela C RintoulOlaf H Drummer
Mar 9, 2013·Evidence-based Medicine·Edward C Lauterbach
Apr 17, 2013·European Journal of Clinical Pharmacology·François MontastrucUNKNOWN REAL.FR Group
Jun 5, 2013·Sleep·Poul JennumJakob Kjellberg
Citations
Apr 20, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Andrea TicinesiTiziana Meschi
Mar 10, 2016·BMJ Open·Poul JennumJakob Kjellberg
Aug 3, 2016·Psychopharmacology·Suzanne ReevesRobert Howard
Mar 24, 2017·Brain : a Journal of Neurology·Suzanne ReevesRobert Howard
Apr 27, 2017·Nursing·Joshua E Palmer
May 27, 2017·BMC Pharmacology & Toxicology·Jon BrännströmYngve Gustafson
Sep 7, 2017·Journal of Sleep Research·Dieter RiemannKai Spiegelhalder
Dec 5, 2017·International Psychogeriatrics·Mitchell McMasterUNKNOWN AusQoL Group
Dec 23, 2017·Dementia·Stephen J Ralph, Anthony J Espinet
Nov 17, 2017·International Journal of Geriatric Psychiatry·Laura SaarelainenHeidi Taipale
Jan 15, 2019·PloS One·Yong DuHildtraud Knopf
Nov 28, 2018·JAD Reports·Stephen J Ralph, Anthony J Espinet
Feb 6, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A EgebergU Mrowietz
Mar 13, 2020·The British Journal of Dermatology·H YenC-C Chi
Mar 7, 2018·Reviews in the Neurosciences·Man AmanatNima Rezaei
Jun 24, 2017·International Journal of Geriatric Psychiatry·Suzanne ReevesRobert Howard
Feb 10, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I J A de BruinF de Vries
Jun 19, 2019·Therapeutic Advances in Chronic Disease·Jian-An SuChung-Ying Lin
Mar 31, 2019·Scientific Reports·Sofia GustafssonIrena Loryan
Apr 28, 2017·Alzheimer's Research & Therapy·Karim TifrateneRenaud David
May 4, 2017·International Journal of Dental Hygiene·A TiisanojaP Ylöstalo
Oct 15, 2020·Psychological Medicine·Robert Whitaker
Jun 8, 2021·Neurobiology of Sleep and Circadian Rhythms·Lone Baandrup, Poul J Jennum
Jun 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yan-Hua LinYong-Mei Song