PMID: 6097321Oct 1, 1984Paper

Increased alpha 1-adrenergic receptor density in brown adipose tissue of cafeteria-fed rats

Bioscience Reports
A RaasmajaJ Nedergaard


A possible general corollary between alpha 1-receptor density in brown adipose tissue and the degree of activation of the tissue was investigated. For this purpose, the effect of cafeteria feeding on alpha 1-adrenergic receptors in brown adipose tissue of seven-week-old female rats was studied by the use of the alpha 1-antagonist (3H)-prazosin. In cafeteria-fed rats, the KD of the alpha 1-receptor for (3H)prazosin was unchanged (about 0.35 nM), but the receptor density was doubled (up to 40 fmol per mg of membrane protein). This was also observed when the results were expressed per unit of a plasma-membrane marker (5'-nucleotidase). It was concluded that an increased alpha 1-receptor density is seen not only in cold-acclimated rats, but also in other conditions where brown fat is activated, and a possible general physiological significance of alpha 1-adrenergic pathways in brown adipose tissue is discussed.


Sep 6, 1979·Nature·N J Rothwell, M J Stock
Aug 16, 1984·Biochemical and Biophysical Research Communications·J NedergaardB Cannon
Dec 1, 1980·Biochemical Pharmacology·J A Garcia-SáinzJ N Fain
Jul 20, 1984·Biochimica Et Biophysica Acta·E NånbergB Cannon
May 1, 1983·The American Journal of Physiology·R J SchimmelK K McMahon
May 15, 1984·European Journal of Biochemistry·E ConnollyJ Nedergaard
Jan 1, 1983·Differentiation; Research in Biological Diversity·R J Scott, G C Yeoh
Jan 1, 1982·International Review of Cytology·J Nedergaard, O Lindberg
Dec 13, 1982·FEBS Letters·B CannonJ Nedergaard
May 1, 1982·The Journal of Clinical Investigation·J B YoungL Landsberg

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Aug 15, 1985·European Journal of Pharmacology·N J RothwellD K Sudera
Jun 24, 1986·European Journal of Pharmacology·N J RothwellD K Sudera
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Jan 1, 1986·Bioscience Reports·N J Rothwell, M J Stock

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