PMID: 6511981Dec 1, 1984

Increased ammoniagenesis and the renal tubular effects of potassium depletion

Journal of Clinical Pathology
D S O'Reilly


The cause of the morphological changes and functional defects in the renal tubule seen in patients with severe potassium depletion is unknown. In man and animals potassium status is a major factor regulating ammonia synthesis in the kidney and urinary ammonium excretion. A primary effect of potassium depletion is to cause an increase in ammoniagenesis by the renal tubular cells. It is proposed that the vacuolation of the renal tubular cells and the functional defects of tubular proteinuria, polyuria, resistance to arginine vasopressin, renal resistance to the action of parathyroid hormone, and increased urinary excretion of N-acetyl-beta-glucosaminidase found in potassium depletion are secondary effects caused by high concentrations of ammonia in the renal tubular cells.


Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S Ohkuma, B Poole
Jan 1, 1975·The American Journal of Physiology·N Beck, B B Davis
Oct 1, 1976·The American Journal of Physiology·N Beck, S K Webster
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A McKannaS Cohen
May 1, 1975·Kidney International·W R Adam, D P Simpson
Feb 8, 1979·European Journal of Pediatrics·K TadaS Yamada
Aug 1, 1976·The Journal of Clinical Investigation·R T BoguskyJ M Lowenstein
Jul 1, 1976·The American Journal of Physiology·R L Tannen, A S Kunin
Oct 1, 1976·The American Journal of Physiology·R L Tannen, J McGill
Sep 2, 1975·Biochemical and Biophysical Research Communications·P O Seglen
Oct 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·A IshiharaH Uehara
Sep 15, 1974·Biochemical Pharmacology·C de DuveF Van Hoof
Jun 1, 1973·The American Journal of Physiology·D E Kamm, G L Strope
Sep 1, 1973·The Journal of Clinical Investigation·R L TannenR Moore
Apr 1, 1970·The Journal of Clinical Investigation·R L Tannen
Oct 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·C H Gips, M Wibbens-Alberts
Oct 1, 1967·The Journal of Clinical Investigation·W J StoneR F Pitts
Feb 1, 1982·Kidney International·R S SleeperH G Preuss
Sep 1, 1981·The Journal of Cell Biology·B Poole, S Ohkuma
Mar 1, 1980·Experimental Cell Research·P G de GrootJ M Tager
Jul 1, 1982·Annals of Clinical Biochemistry·D B Morgan
Jun 15, 1980·The Biochemical Journal·D W Riches, D R Stanworth
Nov 9, 1981·Biochimica Et Biophysica Acta·D Kleiner
Sep 1, 1981·Kidney International·S Sastrasinh, R L Tannen
Mar 1, 1953·The Journal of Clinical Investigation·W B SCHWARTZ, A S RELMAN
Aug 2, 1956·The New England Journal of Medicine·A S RELMAN, W B SCHWARTZ
Dec 1, 1956·The Journal of Clinical Investigation·A C CORCORANI H PAGE
Jan 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·E A BUTLERE B ROBSON
Sep 1, 1951·The American Journal of Medicine·D P EARLEN J CONAN
Feb 2, 1952·Lancet·D A K BLACK, M D MILNE


Oct 1, 1991·Kidney International·A TizianelloG Deferrari
Nov 21, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Ratree TavichakorntrakoolVisith Thongboonkerd
Apr 11, 2018·The Journal of Biological Chemistry·Cheng FangYong Juan Zhao
Dec 10, 2016·The American Journal of Clinical Nutrition·Michele F EisengaMichel M Joosten

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