Increased Amplitude of the P3a ERP Component as a Neurocognitive Marker for Differentiating Amnestic Subtypes of Mild Cognitive Impairment

Frontiers in Aging Neuroscience
Kenia S Correa-JarabaFernando Díaz

Abstract

The event-related potential (ERP) technique has been shown to be useful for evaluating changes in brain electrical activity associated with different cognitive processes, particularly in Alzheimer's disease (AD). Longitudinal studies have shown that a high proportion of people with amnestic mild cognitive impairment (aMCI) go on to develop AD. aMCI is divided into two subtypes according to the presence of memory impairment only (single-domain aMCI: sdaMCI) or impairment of memory and other cognitive domains (multi-domain aMCI: mdaMCI). The main aim of this study was to examine the effects of sdaMCI and mdaMCI on the P3a ERP component associated with the involuntary orientation of attention toward unattended infrequent novel auditory stimuli. Participants performed an auditory-visual distraction-attention task, in which they were asked to ignore the auditory stimuli (standard, deviant, and novel) and to attend to the visual stimuli (responding to some of them: Go stimuli). P3a was identified in the NovelminusStandard difference waveforms, and reaction times (RTs) and hits (in response to Go stimuli) were also analyzed. Participants were classified into three groups: Control, 20 adults (mean age (M): 65.8 years); sdaMCI, 19 adult...Continue Reading

References

Apr 1, 1975·Electroencephalography and Clinical Neurophysiology·N K SquiresS A Hillyard
Aug 1, 1975·Electroencephalography and Clinical Neurophysiology·E CourchesneR Galambos
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Sep 14, 1991·BMJ : British Medical Journal·N LynöeL Jacobsson
Nov 13, 1989·Brain Research·R T KnightC C Clayworth
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Feb 1, 1984·Electroencephalography and Clinical Neurophysiology·R T Knight
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Apr 1, 1995·Electroencephalography and Clinical Neurophysiology·P BaudenaJ M Clarke
Aug 1, 1997·Electroencephalography and Clinical Neurophysiology·Y M Cycowicz, D Friedman
Aug 26, 1998·Psychophysiology·D FriedmanY M Cycowicz
Nov 6, 1998·Journal of Cognitive Neuroscience·C EsceraR Näätänen
Feb 19, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S YamaguchiS Kobayashi
Jun 8, 2001·Zeitschrift für Gerontologie und Geriatrie·H Bickel
Jul 11, 2001·Neuroscience and Biobehavioral Reviews·D FriedmanH Gaeta
Dec 24, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Maria Dolores PoloCarles Grau
Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T LepistöE T Aronen
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Jun 25, 2005·Current Alzheimer Research·Eiichi KatadaRyuzo Ueda
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J D Fisk, K Rockwood
Aug 30, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Sophie BaudicLatchezar Traykov
Aug 9, 2006·Archives of General Psychiatry·Matthias H TabertD P Devanand
Sep 26, 2006·Neurobiology of Aging·Anne HämäläinenHilkka Soininen
Oct 4, 2006·Journal of Cognitive Neuroscience·Francisco BarceloJose A Periáñez
Dec 22, 2006·The New England Journal of Medicine·Gary W SmallJorge R Barrio
Nov 21, 2007·Neurobiology of Aging·János HorváthJudit Gervai
Jan 12, 2008·Journal of Advanced Nursing·Ercole VelloneMarlene Zichi Cohen
Jan 22, 2008·CNS Spectrums·Ronald C Petersen, Selamawit Negash
May 13, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Georg JuckelUlrich Hegerl
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Colleen E Jackson, Peter J Snyder
Nov 20, 2008·The Open Neuroimaging Journal·Paolo CaffarraAnnalena Venneri
Nov 10, 2009·Behavior Research Methods·Franz FaulAlbert-Georg Lang
Jun 2, 2011·International Journal of Alzheimer's Disease·Fabrizio Vecchio, Sara Määttä

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