Increased angiotensin II in ascites during severe ovarian hyperstimulation syndrome: role of early pregnancy and ovarian gonadotropin stimulation

Fertility and Sterility
A DelbaereY Englert

Abstract

To investigate the implications of the ovarian renin-angiotensin system (RAS) in the pathophysiology of the ovarian hyperstimulation syndrome (OHSS) in relation to gonadotropin stimulation and early pregnancy. A controlled clinical study comparing blood and simultaneously sampled peritoneal fluid (PF) from patients with severe OHSS and from controls without OHSS. University Hospitals. Eleven patients with severe OHSS, 8 patients with ascites of other origin, 9 patients with a first-trimester pregnancy, and 15 patients stimulated with gonadotropins for IVF. Angiotensin II immunoreactivity was measured in blood and PF and analyzed by high-performance liquid chromatography (HPLC) in ascites from OHSS. Angiotensin II immunoreactivity (pg/mL; mean +/- SE) was highest in the ascites from pregnant OHSS (1,669 +/- 418), reaching levels 5 times higher than in the plasma (331 +/- 61) and 100 times higher than in control ascites (17 +/- 6.7). Angiotensin II immunoreactivity was elevated in the PF during early pregnancy (211 +/- 68) and after gonadotropin stimulation (244 +/- 41) and was higher than in the plasma in both groups. Analysis by HPLC showed that the majority of Ang II immunoreactivity in the ascites of OHSS was because of true ...Continue Reading

References

Oct 1, 1992·Journal of Assisted Reproduction and Genetics·P A Bergh, D Navot
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·F H DerkxM A Schalekamp
Jan 1, 1989·American Journal of Obstetrics and Gynecology·A PalumboF Naftolin
Jun 1, 1989·Obstetrical & Gynecological Survey·A GolanE Caspi
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J ItskovitzZ Rosenwaks
Mar 1, 1986·The Journal of Clinical Endocrinology and Metabolism·M D CullerF Naftolin
Dec 1, 1972·Circulation Research·A L Robertson, P A Khairallah
Feb 15, 1984·American Journal of Obstetrics and Gynecology·C R Rosenfeld, G M Jackson
Mar 1, 1980·British Journal of Obstetrics and Gynaecology·P R KoninckxI A Brosens

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Citations

Apr 9, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nikoletta PanagiotopoulouKalsang Bhatia
Dec 5, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·T HanaiS Inamoto
Aug 22, 2003·The New England Journal of Medicine·Guillaume SmitsSabine Costagliola
Jan 1, 2012·Case Reports in Critical Care·Nisha Rani AgrawalNeeraj Varyani
Jul 28, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Veerle VloeberghsThomas D'Hooghe
Jan 11, 2000·Baillière's Clinical Obstetrics and Gynaecology·H S Jacobs, R Agrawal
Nov 5, 2016·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Nov 9, 2016·Reproductive Sciences·Angela PalumboFrederick Naftolin
Oct 14, 2014·Clinical and Experimental Reproductive Medicine·Mi Kyoung KimTae Ki Yoon
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Tzu-Hao WangYung-Kuei Soong

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