Increased anti-Mullerian hormone levels and ovarian size in a subgroup of women with functional hypothalamic amenorrhea: further identification of the link between polycystic ovary syndrome and functional hypothalamic amenorrhea

American Journal of Obstetrics and Gynecology
Enrico CarminaRoger A Lobo

Abstract

Functional hypothalamic amenorrhea is a disorder characterized by cessation of menstrual cycles in the absence of organic disease. In most patients, it occurs in adult life after a stressful event and may be related to a condition of mild chronic energy deprivation. The endocrine pattern is characterized by low estrogen levels with an absent response to a progestogen challenge test and low-normal gonadotropin levels. A few studies have shown that some of these women may have some features of polycystic ovary syndrome; these features include an increased androgen response to gonadotropins, increased anti-Mullerian hormone levels, and altered ovarian morphology or increased ovarian size. These findings suggest a link between these 2 completely different disorders: functional hypothalamic amenorrhea and polycystic ovary syndrome. The importance of the possible coexistence of these disorders in some women is important for follow-up of these women and in their treatment if they desire to become pregnant. To determine whether a subgroup of well-characterized women with functional hypothalamic amenorrhea may have the coexistence of polycystic ovary syndrome. Retrospective analysis of women with functional hypothalamic amenorrhea. Fort...Continue Reading

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Nov 3, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Enrico CarminaRogerio A Lobo

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Citations

May 7, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Didier Dewailly
Oct 28, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Enrico CarminaRoger A Lobo
Mar 15, 2020·The Journal of Clinical Endocrinology and Metabolism·Amoon AlemyarJoop S E Laven
Oct 11, 2020·International Journal of Molecular Sciences·Chioma Izzi-EngbeayaWaljit S Dhillo
Apr 15, 2021·Endocrine Reviews·Nathalie di ClementeJoëlle Taieb

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