Increased anticipatory brain response to pleasant touch in women remitted from bulimia nervosa.

Translational Psychiatry
Christina E WierengaWalter H Kaye

Abstract

Bulimia nervosa (BN) is characterized by affective instability and dysregulated behaviors (binge eating, fasting, self-induced vomiting) that disrupt bodily homeostasis. Mechanisms underlying dysregulation in BN are unclear, although altered reward responsivity, anticipatory processing of environmental cues, and interoception (detection and integration of body-state signals to regulate behavior) have been implicated in BN pathophysiology. We aimed to determine whether BN is associated with ineffectively predicting body state or integrating predicted experience with actual experience by examining neural response to anticipation and experience of affective touch, a pleasant interoceptive stimulus that acts on sensory and emotional systems to guide behavior. During fMRI, we administered soft strokes to the palm and forearm in women remitted from BN (RBN; N = 23) and control women (CW; N = 25). A Group (RBN/CW) × Condition (anticipation/touch) interaction was found in the right dorsal caudate; both CW and RBN had increased activation during touch compared with anticipation, with RBN demonstrating marginally greater anticipatory response than CW. For RBN, those individuals who showed greater anticipatory response in the dorsal cauda...Continue Reading

References

Jun 1, 1991·Biological Psychiatry·S LautenbacherJ C Krieg
Apr 1, 1996·Current Opinion in Neurobiology·T W Robbins, B J Everitt
Jul 1, 1996·Journal of Psychosomatic Research·M de ZwaanG Stacher
Jan 1, 1997·Schizophrenia Bulletin·A M Graybiel
Jul 30, 2002·Nature Neuroscience·H OlaussonM C Bushnell
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Sep 2, 2003·The International Journal of Eating Disorders·Daniel SteinRhadika Rao
Sep 11, 2003·Current Opinion in Neurobiology·A D Craig
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Oct 24, 2003·Biological Psychiatry·B Timothy WalshHarry R Kissileff
Aug 28, 2004·Eating and Weight Disorders : EWD·S FassinoG Abbate Daga
Feb 24, 2005·Psychological Medicine·Kelly L KlumpWalter H Kaye
Apr 5, 2005·Journal of Psychiatric Research·H PapezováR Uher
Apr 6, 2005·NeuroImage·Thomas NicholsJean-Baptiste Poline
Jun 2, 2005·Journal of Neurophysiology·Arthur AronLucy L Brown
Jul 30, 2005·The Journal of Comparative Neurology·Julie L FudgeValerie Pannoni
Aug 16, 2005·Clinical Psychology Review·Stephanie E Cassin, Kristin M von Ranson
Oct 29, 2005·The International Journal of Eating Disorders·Guido K FrankWalter H Kaye
Mar 11, 2006·The International Journal of Eating Disorders·Angela WagnerWalter H Kaye
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowChristopher Wong
May 16, 2008·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornPeter Westfall
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Jan 7, 2009·Archives of General Psychiatry·Rachel MarshBradley S Peterson
Mar 13, 2009·NeuroImage·Kathryn L LoveroMartin P Paulus
Apr 14, 2009·Nature Neuroscience·Line S LökenHåkan Olausson
May 13, 2009·The International Journal of Eating Disorders·Angela WagnerWalter H Kaye
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Nov 3, 2009·Nature Neuroscience·Sahib S KhalsaDaniel Tranel
Apr 15, 2010·Brain Research·Kent C BerridgeAlexandra G DiFeliceantonio
Jun 15, 2011·NeuroImage·Andrea BrovelliDriss Boussaoud
Jul 2, 2011·Biological Psychiatry·Guido K W FrankRandall C O'Reilly
Oct 15, 2011·The International Journal of Eating Disorders·Cara Bohon, Eric Stice
Jun 29, 2013·Drug and Alcohol Dependence·April C MayMartin P Paulus
Oct 12, 2013·Frontiers in Psychology·Laura CrucianelliPaul M Jenkinson

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Citations

Jan 7, 2021·Current Psychiatry Reports·Lisa M AndersonErin E Reilly

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Software Mentioned

R
AFNI
multcomp package
SPMG3
multcomp
FSL
3dClustSim

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