PMID: 3744469Sep 1, 1986Paper

Increased aortic DNA synthesis precedes renal hypertension in rats. An obligatory step?

Hypertension
A L LoebB L Bean

Abstract

The rate of DNA synthesis was determined in rats with developing and established two-kidney, one clip renal hypertension. Rate of DNA synthesis was measured as [3H]thymidine incorporation into DNA per hour. After stenosis of the renal artery, blood pressure increased over a 2-week period. Five days after clipping, there was an increase in the rate of aortic DNA synthesis before an increase in blood pressure was detected, whereas there was no DNA effect in sham-operated animals. This difference in [3H]thymidine incorporation into aortic DNA could not be accounted for by alterations in thymidine pool sizes. The increase in DNA synthesis was still present 3 weeks after renal artery stenosis, although by that time blood pressure had plateaued. The role of DNA synthesis in the development of renal hypertension was investigated by determining whether inhibition of DNA synthesis with cytosine arabinoside could prevent the increase in blood pressure. Treatment of clipped rats with cytosine arabinoside for 5 days delayed the increase in blood pressure for more than 4 days, as compared with the effect of saline treatment in clipped rats. Although the possibility remains that some effect of cytosine arabinoside other than its effect on DN...Continue Reading

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Citations

Nov 1, 1992·Molecular Biology Reports·J W van Neck, H P Bloemers
Oct 1, 1989·Kidney International·Y YoshidaI Ichikawa
Dec 14, 1987·The American Journal of Cardiology·M J Peach, A L Loeb
Oct 1, 1988·Experimental and Molecular Pathology·D W Crawford, D M Kramsch
Jul 1, 1988·International Journal of Cardiology·A M HeagertyS J Bund
Oct 5, 1988·The American Journal of Cardiology·V J Dzau, G H Gibbons
Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R C SharmaQ Jiao
Dec 1, 1992·Hypertension·C L Jackson, S M Schwartz
Dec 25, 2002·Acta Veterinaria Hungarica·I BiksiE Fenyö

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