PMID: 7059324Jan 1, 1982Paper

Increased apoprotein B in very low density lipoproteins of patients with peripheral vascular disease

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
G FranceschiniC R Sirtori

Abstract

Lipoprotein compositional studies were carried out in 20 patients with atherosclerotic peripheral vascular disease. Twelve of these patients were normolipidemic, the other eight, hypertriglyceridemic. Ten normolipidemic and 10 hypertriglyceridemic age-matched subjects were used as controls. High density lipoprotein cholesterol levels were markedly reduced in the hypertriglyceridemic subjects, both with (35.1 +/- 5.0 mg/dl) and without (36.2 +/- 11.7 mg/dl) peripheral vascular disease, as compared to the normolipidemic patients (47.0 +/- 6.3 mg/dl) and controls (48.1 +/- 10.0 mg/dl). A decreased relative content of apo C-11 in very low density lipoproteins in the hypertriglyceridemic subjects, as compared to the normolipidemics, was detected by isoelectric focusing. Hypertriglyceridemia in patients with peripheral vascular disease shows a typical Type IV lipoprotein and apoprotein profile. Apoprotein B levels in very and low density lipoproteins were determined by electroimmunodiffusion and selective precipitation with tetramethylurea (r = 0.981 between the two methods). All the patients with peripheral vascular disease showed an increased apo B content in very low density lipoproteins vascular disease showed an increased apo B ...Continue Reading

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·C R Sirtori, G Franceschini
Oct 1, 1988·European Journal of Vascular Surgery·F G Fowkes
Jun 3, 1985·Klinische Wochenschrift·C R Sirtori, G Franceschini
Nov 1, 1990·Annals of Vascular Surgery·J H Rapp
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May 30, 1998·The American Journal of Cardiology·C R Sirtori

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