PMID: 2502369Jun 20, 1989Paper

Increased arachidonic acid uptake by platelets from insulin-dependent diabetics and diabetic rats

Diabetes Research and Clinical Practice
C PerezJ E Campillo

Abstract

14C-Arachidonic acid uptake was measured in platelets obtained from 15 insulin-dependent diabetic and 17 control subjects and in 12 streptozotocin-diabetic and 21 control rats. The 14C-arachidonic acid uptake, expressed as pmol/10(8) platelets/min, mean +/- SEM, was significantly higher in platelets from diabetic subjects (2.80 +/- 0.23) and diabetic rats (1.73 +/- 0.20) than in the control subjects (2.29 +/- 0.15) and the control rats (1.35 +/- 0.08). No significant correlations were found between arachidonic acid uptake and glucose, total cholesterol or triglyceride plasma levels in either rats or humans. Arachidonic acid uptake was inhibited by indometacin but not by nordihydroguaiaretic acid, in diabetic as well as in control subjects. The present results suggest that the increased arachidonic acid uptake by platelets from insulin-dependent diabetic patients and streptozotocin-diabetic rats depends on their increased platelet arachidonic acid utilization through the cyclooxygenase pathway.

References

Oct 1, 1985·Diabetes·G ThomasO P Schumacher
Jul 1, 1983·Annals of Internal Medicine·B PittB R Lucchesi
Sep 1, 1984·Current Eye Research·N Naveh-FlomanM Belkin

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Citations

Apr 1, 1992·Diabetes/metabolism Reviews·H IshiiH Nawata
Sep 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A Q DangW J Carter
Jan 1, 1996·Platelets·A K Dutta-RoyL C Crosbie
Jul 2, 2004·Experimental Biology and Medicine·Sonhee C ParkM Judith Radin

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