Mar 15, 2005

Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine
Hiroyasu YasudaHidetada Sasaki

Abstract

Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases. To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. We measured arterial Hb-CO, arteriovenous Hb-CO differences, and FEV1 in 58 patients with COPD and 61 ex-smoking control subjects. Arterial Hb-CO concentrations in patients at stable conditions were higher than those in control subjects (p < 0.0001). Furthermore, the Hb-CO concentrations in patients at the exacerbations (p < 0.0001) were higher than those at the stable conditions. Arterial Hb-CO concentrations in patients at stage III were higher than those in patients at stage II, and the Hb-CO concentrations in patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO in patients with COPD at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. Arteriovenous Hb-CO differences in patients at the exacerbations did not differ from those in patients at stable condi...Continue Reading

  • References42
  • Citations36

Citations

Mentioned in this Paper

Chronic Airflow Obstruction
Breathalyzer Tests
C-reactive Protein Measurement
Expiration, Function
Lung
Carboxyhemoglobin
COPD pharmacologic substance
Carboxyhemoglobin C
Lung Diseases
Inflammation

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.