May 16, 2014

Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Ahmed TawakolSteven Grinspoon


Mechanisms predisposing HIV-infected patients to increased cardiovascular disease (CVD) risk remain unclear. To determine the interrelationship between arterial inflammation and high-risk coronary plaque morphology in HIV-infected patients with subclinical coronary atherosclerosis. Forty-one HIV-infected patients on stable antiretroviral therapy without known CVD but with atherosclerotic plaque on coronary CT angiography were evaluated with F-FDG-PET. Patients were stratified into 2 groups based on relative degree of arterial inflammation [aortic target-to-background ratio (TBR)]. High-risk coronary atherosclerotic plaque morphology features were compared between groups. HIV-infected patients with higher and lower TBRs were similar with respect to traditional CVD risk parameters. Among HIV-infected patients with higher TBR, an increased percentage of patients demonstrated at least 1 low-attenuation coronary atherosclerotic plaque (40% vs. 10%, P = 0.02) and at least 1 coronary atherosclerotic plaque with both low attenuation and positive remodeling (35% vs. 10%, P = 0.04). Moreover, in the higher TBR group, both the number of low-attenuation plaques per patient (P = 0.02) and the number of vulnerability features in the most vul...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Plaque, Atherosclerotic
Positron-Emission Tomography
Coronary Artery Disease
Anti-Retroviral Agents
Log-Linear Models
FDG-Positron Emission Tomography
Science of Morphology
HIV Infections
Dental Plaque

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