Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly

Clinical Endocrinology
Annamaria ColaoGaetano Lombardi

Abstract

Patients with acromegaly have an increased morbidity and mortality for cardiovascular diseases. Despite the increasing evidence for the existence of a specific cardiomyopathy in acromegaly, the presence of vascular abnormalities has been never investigated. To evaluate the cardiovascular risk and premature atherosclerosis in acromegaly. Forty-five patients with acromegaly and 30 sex- and age-matched healthy subjects were included in this study: 30 patients were studied at the diagnosis of acromegaly and were in active disease (GH 59.3 +/- 10.2 mU/l, IGF-I 733 +/- 57.6 microg/l) while 15 patients were studied after surgery and/or radiotherapy and were cured from the disease (GH 4.5 +/- 0.7 mU/l, IGF-I 172.4 +/- 16.9 microg/l). Body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), serum total, LDL- and HDL-cholesterol, triglycerides, and fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (APTT), glucose and insulin levels (fasting and after glucose load) were measured in all patients and controls. By echodoppler ultrasonography, blood systolic (SPV) and diastolic (DPV) peak velocity, and resistance index (RI) were measured at both common and internal carotid arteries where presence...Continue Reading

References

Jan 1, 1991·Journal of Endocrinological Investigation·J L PereiraR Astorga
Apr 5, 1990·The New England Journal of Medicine·S Melmed
Dec 15, 1990·Annals of Internal Medicine·P ChansonJ Lubetzki
Apr 1, 1987·Clinical Endocrinology·J D Nabarro
Oct 1, 1994·Endocrine Reviews·L SaccàS Fazio
Jul 1, 1994·The Journal of Clinical Endocrinology and Metabolism·K C Copeland, K S Nair
Feb 1, 1993·Kidney International·R HirschbergH P Guler
Jan 1, 1997·Clinical Endocrinology·B BülowE M Erfurth
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·B CapaldoL Saccà
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Mar 4, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J A JanssenS W Lamberts
Nov 10, 1998·Lancet·A Colao, G Lombardi
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Mar 23, 1999·Circulation·A FrustaciA Maseri
Apr 21, 1999·Clinical Endocrinology·P ChansonD Chemla
May 5, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J IsgaardB A Bengtsson

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Citations

Dec 29, 2007·Reviews in Endocrine & Metabolic Disorders·Annamaria ColaoGaetano Lombardi
Feb 3, 2011·The Journal of Physiological Sciences : JPS·Mei-Hua JinSusumu Minamisawa
Apr 22, 2008·International Journal of Clinical Practice·I KartalF Alagöl
Apr 21, 2012·International Journal of Endocrinology·Gloria LugoFernando Cordido
Oct 19, 2006·Neuroendocrinology·Gaetano LombardiAnnamaria Colao
Jan 12, 2010·The Journal of Clinical Endocrinology and Metabolism·Karen K MillerAnne Klibanski
May 29, 2008·Endocrine Journal·Haruna SakaiYukio Hirata
Feb 11, 2010·European Journal of Endocrinology·Hiroyoshi AkutsuChristof Schöfl
Sep 16, 2006·European Journal of Pediatrics·Esad KokluTamer Gunes
Oct 23, 2013·Seminars in Diagnostic Pathology·Adriana LukJagdish Butany
Mar 1, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Hitoshi NishizawaYutaka Takahashi
Mar 10, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ashley S IzzardAnthony M Heagerty
Jun 21, 2005·Clinical Endocrinology·Josef V SilhaLiam J Murphy
Jan 16, 2008·Clinical Endocrinology·Sideris P DelaroudisAvraam I Avramides
May 9, 2008·Clinical Endocrinology·Annamaria Colao
Jan 9, 2009·Clinical Endocrinology·L BoeroF Brites
Dec 21, 2011·Clinical Endocrinology·Pier P BassareoGiuseppe Mercuro
Mar 10, 2007·International Journal of Cardiology·Attila NemesMiklós Csanády
Sep 28, 2002·Diabetes Care·Eeva S LeinonenMarja-Riitta Taskinen
Jun 10, 2016·Pituitary·Alin AbreuMarcello D Bronstein
Feb 6, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Güven Barış CansuHasan Ali Altunbaş
Dec 10, 2015·São Paulo Medical Journal = Revista Paulista De Medicina·Marcelo Palmeira RodriguesLuiz Augusto Casulari
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Giselle F TaboadaMônica R Gadelha
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo FadiniPietro Maffei
Sep 24, 2005·Annals of Medicine·Mirella HietaniemiY Antero Kesäniemi
Aug 30, 2005·Blood Pressure·Vanessa RonconiLaura Mazzanti
Jan 16, 2007·Journal of Cardiovascular Pharmacology and Therapeutics·Ernst R SchwarzSalvatore Rosanio
Dec 31, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Shin-ichi KawachiKeigo Yasuda
Jun 6, 2003·Endocrine Reviews·R N Clayton
Jan 29, 2009·The Journal of Clinical Endocrinology and Metabolism·Angela N PaisleyAnthony M Heagerty
Feb 9, 2012·Cardiology in Review·Christopher R PalmeiroIrene A Weiss
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Gemma SesmiloAnne Klibanski
Sep 28, 2005·Clinical Science·Irene J AnderssonGöran Bergström
Feb 11, 2004·Endocrine Reviews·Annamaria ColaoGaetano Lombardi

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