Increased arterial stiffness and indication of endothelial dysfunction in long-standing rheumatoid arthritis

Scandinavian Journal of Rheumatology
S Wållberg-JonssonS Rantapää-Dahlqvist

Abstract

Atherosclerotic progression is accelerated in rheumatoid arthritis (RA). We evaluated arterial stiffness and endothelial dysfunction in RA patients and controls by pulse wave analysis (PWA). Thirty RA patients with long-standing disease and 30 age- and sex-matched controls were examined using applanation tonometry of the radial artery before and after vasodilation by terbutaline (endothelium dependent) and nitroglycerin (endothelium independent). The aortic augmentation index (AIx) and time to reflected wave (transit time, Tr) were measured. Using the peripheral pulse curve, the stiffness index (SI) and the reflectance index (RI) were calculated. Tr and SI predominantly reflect large artery stiffness, whereas Aix and RI also reflect small vessel resistance. The PWA measurements were assessed in relation to adhesion molecules [soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intracellular adhesion molecule-1 (sICAM-1)], selectins (E, L and P), and inflammation [erythrocyte sedimentation rate (ESR), haptoglobin, interleukin (IL)-6, IL-1 receptor antagonist (IL-1-Ra), IL-2-soluble receptor (IL-2sR), and tumour necrosis factor receptors-I and -II (TNFR...Continue Reading

Associated Clinical Trials

Sep 12, 2018·Mónica VázquezdelMercadoEspinosa

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Citations

Sep 20, 2011·Rheumatology·Aamer SandooGeorge D Kitas
Apr 3, 2010·The Open Cardiovascular Medicine Journal·George S MetsiosGeorge D Kitas
Sep 4, 2008·Scandinavian Journal of Rheumatology·A SyngleS Sharma
Oct 23, 2012·The American Journal of the Medical Sciences·Jung-Yeon HanSoon-Pyo Hong
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Jiayun ShenLai-Shan Tam
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Apr 1, 2011·Arthritis Care & Research·Henry R Kramer, Jon T Giles
Dec 3, 2014·Atherosclerosis·Snigdha JainJulio A Chirinos
Dec 29, 2010·Journal of Cardiovascular Disease Research·Hamdy Sliem, Gamela Nasr
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Feb 15, 2020·Current Vascular Pharmacology·Maria DrakopoulouKonstantinos Toutouzas

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