Increased arterial stiffness in cyclosporine-treated lung transplant recipients early after transplantation

Clinical Transplantation
Martin SilverbornAnders Jeppsson

Abstract

The majority of patients undergoing solid organ transplantation develop hypertension, to which cyclosporine (CsA)-induced peripheral vasoconstriction may contribute. We hypothesized that CsA-treated transplant recipients have an increased basal vascular tone and an altered response to nitric oxide. To test this hypothesis arterial resistance, non-endothelial dependent relaxation and arterial stiffness were investigated in CsA-treated lung transplant recipients within 18 months after transplantation. In study 1, forearm blood flow (FBF) was measured by venous occlusion plethysmography at baseline and during glyceryl trinitrate (GTN) and N(G)-monomethyl-l-arginine acetate (l-NMMA) infusion in seven lung transplant recipients and nine healthy subjects. In study 2, arterial stiffness in carotid (CCA) and radial artery (RA) was measured by ultrasound (echo-tracking) in 10 lung transplant recipients, 12 healthy subjects and six patients waiting for lung transplantation. Basal FBF (3.1 +/- 0.2 vs. 3.0 +/- 0.3 mL/min, p = 0.79) and forearm arterial resistance (36 +/- 3 vs. 33 +/- 3 mmHg/mL/min, p = 0.60) did not differ between transplant recipients and controls. GTN infusion increased and l-NMMA decreased blood flow equally in both gro...Continue Reading

References

Feb 1, 1992·Journal of the American Society of Nephrology : JASN·D DiederichT F Lüscher
Jul 1, 1991·The Journal of Clinical Investigation·T E Bunchman, C A Brookshire
May 1, 1991·American Journal of Hypertension·R G Luke
Sep 13, 1990·The New England Journal of Medicine·U ScherrerR G Victor
Apr 1, 1989·Hypertension·H Meyer-Lehnert, R W Schrier
Jun 8, 1989·European Journal of Pharmacology·C BossallerE Fleck
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A C OngJ F Moorhead
Feb 1, 1997·Hypertension·E S StroesT J Rabelink
Jan 12, 1999·Journal of Human Hypertension·G H Jenkins, D R Singer
Mar 30, 2002·Transplantation·Simon D JohnstonJames Neuberger
Aug 6, 2002·American Journal of Hypertension·Gérard M London, Jay N Cohn
Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marshall I HertzBerkeley M Keck
Oct 24, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Leslie W Miller

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Citations

Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Martin SilverbornAnders Jeppsson
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Martin SilverbornFolke Nilsson
Nov 4, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Martin SilverbornAnders Jeppsson

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