Increased arterial stiffness in normoglycemic normotensive offspring of type 2 diabetic parents

Hypertension
C GiannattasioG Mancia

Abstract

Diabetes is associated with a reduction of arterial distensibility. Limited information exists regarding whether or how early this appears in the course of the disease. We studied 54 normoglycemic, normotensive, healthy offspring of 2 parents with type 2 diabetes mellitus and 55 age- and sex-matched healthy control subjects. Carotid diastolic diameter and systodiastolic change were measured by echo tracking (Wall Track System) and wall thickness by echocolor Doppler (Sonos 5500, Philips). Pulse pressure was measured by a semiautomatic device positioned on the brachial artery and arterial distensibility calculated by Reneman formula. Blood pressure, blood glucose, glycohemoglobin, and insulin sensitivity (homeostasis model assessment index) were normal or only slightly elevated and by and large similar in the 2 groups. Compared with control subjects, offspring of diabetic parents showed similar carotid diameters at diastole and a reduced increase in carotid diameter at systole (-16%), a reduced carotid artery distensibility (-30%), and an increased pulse pressure (+21.8%), all differences being statistically significant (P<0.05) and persisting in subgroups with elevated or normal body mass index values (<25 and >or=25 kg/m(2)). ...Continue Reading

References

Mar 1, 1987·Acta Radiologica·T Christensen, B Neubauer
May 1, 1995·Diabetes Care·M J KoolL M Van Bortel
Jul 1, 1996·Diabetologia·E D LehmannR G Gosling
May 29, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Cyriel J A L MentinkBruce H R Wolffenbuttel
Apr 5, 2003·Kidney International·Jacques BlacherGérard M London
Apr 16, 2003·Circulation·Ronald M A HenryUNKNOWN Hoorn Study
Oct 21, 2003·Journal of Atherosclerosis and Thrombosis·Shigehiko FujiwaraYoshiki Nishizawa
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Ronald M A HenryCoen D A Stehouwer
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·O D McEleavyS J Cleland
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries

❮ Previous
Next ❯

Citations

Oct 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mads HornumBo Feldt-Rasmussen
Dec 10, 2009·Vascular Health and Risk Management·Kevin R ShortKenneth C Copeland
May 20, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alessandro MalobertiCristina Giannattasio
Oct 1, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yi ZhangLin Zheng
Sep 13, 2008·Cardiovascular Therapeutics·Xinkang WangGiora Z Feuerstein
Feb 20, 2016·Clinical Hypertension·Woo-In Yang, Jong-Won Ha
Aug 4, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C CatenaL A Sechi
Mar 6, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Alessandro MalobertiCristina Giannattasio
Dec 10, 2014·Journal of Hypertension·Cristina MenniAna M Valdes
Jan 16, 2008·Hypertension·Stephen P Glasser, Donna K Arnett
Dec 2, 2009·Hypertension·Rupert A PayneDavid J Webb
Jun 22, 2019·The Journal of Clinical Hypertension·Alessandro MalobertiCristina Giannattasio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.