Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country

Respiratory Medicine
V BackerP G Gibson

Abstract

An overlap between obesity and asthma exists, and inflammatory cells in adipose tissue could drive the development of asthma. Comparison of adipose tissue gene expression among Inuit living in Greenland to those in Denmark provides an opportunity to assess how changes in adipose tissue inflammation can be modified by migration and diet. To examine mast cell and inflammatory markers in adipose tissue and the association with asthma. Two Inuit populations were recruited, one living in Greenland and another in Denmark. All underwent adipose subcutaneous biopsy, followed by clinical assessment of asthma, and measurement of AHR. Adipose tissue biopsies were homogenised, RNA extracted, and PCR was performed to determine the relative gene expression of mast cell (tryptase, chymase, CPA3) and inflammatory markers (IL-6, IL-1β, and CD163). Of the 1059 Greenlandic Inuit participants, 556 were living in Greenland and 6.4% had asthma. Asthma was increased in Denmark (9%) compared to Greenland (3.6%, p < 0.0001) and associated with increased adipose tissue IL-6 gene expression and increased BMI. There was no association between asthma and adipose tissue mast cell gene expression. Pro-inflammatory gene expression (IL-6, IL-1β) was higher in ...Continue Reading

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Citations

Aug 30, 2019·Lung India : Official Organ of Indian Chest Society·Ümüş ÖzbeyAliye Gamze Calis
Dec 11, 2019·Nutrients·Urszula RadzikowskaMilena Sokolowska
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Apr 16, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Michael FrickerPeter G Gibson

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