Increased availability of family donors for hematopoietic stem cell transplantation in a population with increased incidence of consanguinity

Clinical Transplantation
Yasemin I BalcıDuygu Uckan

Abstract

The study was planned to determine the frequency of parental and non-sibling family donor transplants in our center and to investigate the rate of familial donor availability at two HLA-typing laboratories in Turkey. Among 203 patients who underwent hematopoietic stem cell transplantation (HSCT), 151 (74.4%) received stem cells from siblings, 48 (23.6%) from non-sibling family donors, two (1.0%) from unrelated cord blood, and two (1.0%) autologous transplantation. Of these 48 patients received stem cells from non-sibling family donors; donors were mothers for 26 (12.8%), fathers for 20 (9.9%), and aunts for two (1.0%). The rate of transplants from parental donors was 22.6% in this patient population with increased frequency of inherited diseases (58.1%). Among these 203 patients, there was consanguinity between parents in 60.6% of the patients. Of 833 subjects applying as donor candidates to HLA-typing laboratories, 527 (63.3%) had HLA 6/6 identical family donors. Among 527 full-matched donors, 479 (90.9%) were sibling, 21 (4.0%) were fathers, and 17 (3.2%) were mothers. The remaining 10 (1.9%) were other relatives. The results have shown that the unfavorable factor of consanguinity marriage may increase the availability of fam...Continue Reading

References

May 1, 1993·The American Journal of Pediatric Hematology/oncology·P J Henslee-Downey
Nov 1, 1996·Current Opinion in Hematology·D J Charron
Sep 25, 1998·Journal of Biosocial Science·R Hussain, A H Bittles
Jun 18, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Juliet N BarkerDaniel J Weisdorf
Mar 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K A B EidC A De Souza
Jun 19, 2004·Annals of Human Biology·M SaadatD D Farhud
Nov 1, 2006·Bone Marrow Transplantation·J M HowsUNKNOWN Late Effects Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Dec 15, 2006·Community Genetics·Hanan HamamyKamel Ajlouni
Dec 18, 2007·Bone Marrow Transplantation·A GratwohlUNKNOWN European Group for Blood and Marrow Transplantation EBMT (JACIE)
Sep 25, 2008·Bone Marrow Transplantation·Gg GanHm Ibrahim
Sep 25, 2008·Bone Marrow Transplantation·D DennisonSs Ganguly
Sep 25, 2008·Bone Marrow Transplantation·Ts ShamsiS Ansari
Sep 25, 2008·Bone Marrow Transplantation·T Wu, D-P Lu
Sep 25, 2008·Bone Marrow Transplantation·F Abdel-RahmanMm Sarhan

❮ Previous
Next ❯

Citations

Mar 30, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Zühre KayaEnes Değirmenci
Sep 26, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kelsey BesseMark Albrecht
Nov 25, 2016·Frontiers in Immunology·Mateja Kralj JuricHildegard T Greinix
Mar 5, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Anu KorulaBiju George

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Bone Marrow Transplantation
A YoshimiAsia-Pacific Blood and Marrow Transplantation Group (APBMT)
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Mahmoud AljurfHassan El Solh
© 2021 Meta ULC. All rights reserved