Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide/long non-coding RNA LSINCT5/caspase-1/interleukin 1β signaling pathway

Molecular Medicine Reports
Xian ZhangDadao Jing

Abstract

Chronic heart failure (CHF) is the final stage of various heart diseases, and is increasingly recognized as a major health problem in the elderly. Previous studies demonstrated that B‑type‑natriuretic peptide (BNP) is an established biomarker of CHF. Furthermore, BNP also regulates cell proliferation, differentiation and apoptosis. Recent evidence has revealed that BNP affects myocardial cell apoptosis during myocardial ischemia‑reperfusion injury. Long non‑coding RNAs (lncRNAs) are emerging as novel molecular compounds involved in gene regulation, and have important roles in numerous human diseases. However, the mechanism underlying the BNP and lncRNA-induced regulation of myocardial cell apoptosis remains to be elucidated. The present study reported that lncRNA LSINCT5, upregulated by BNP, is able to regulate myocardial cell apoptosis via the activation of the caspase‑1/interleukin (IL)‑1β signaling pathway. BNP-induced apoptosis of HCM cells was observed using flow cytometry, and involved caspase‑1. In addition, expression profiling using a human lncRNA polymerase chain reaction array revealed that LSINCT5 was highly expressed in BNP-treated myocardial cells, as compared with untreated cells. The role of lncRNA LSINCT5 in HC...Continue Reading

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Citations

Apr 25, 2019·International Journal of Molecular Sciences·Zhipeng CaoBaoli Zhu
Jun 20, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Bin LiuHui Ma
Mar 14, 2017·International Journal of Molecular Sciences·Jinning GaoPeifeng Li
Jul 14, 2019·Clinical Epigenetics·Yorick JanssensBart De Spiegeleer
Dec 19, 2019·RNA Biology·Shengyun MaWendy Jia Men Huang
Jun 30, 2021·Journal of Thrombosis and Thrombolysis·Xueying TongHezhong Zhu
Aug 22, 2021·Cardiovascular Toxicology·Mehran AmrovaniMozhdeh Sanei

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Methods Mentioned

BETA
flow cytometry
Protein Assay
PCR
Profiler

Software Mentioned

GeneSpring GX
SPSS

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