Increased bacterial resistance: PROTEKT US--an update

The Annals of Pharmacotherapy
Michael J Rybak

Abstract

Community-acquired respiratory tract infections (CARTIs), including community-acquired pneumonia, acute exacerbations of chronic bronchitis, and acute bacterial sinusitis, remain substantial sources of morbidity and mortality in the US. The increasing prevalence of antimicrobial-resistant strains among the common respiratory pathogens, particularly Streptococcus pneumoniae, has complicated the choice of antimicrobials and threatens the efficacy of treatment for CARTIs. This highlights the need both for ongoing surveillance efforts to track current resistance patterns and for the development of new antimicrobial agents effective against resistant organisms. To provide current and ongoing antimicrobial resistance surveillance data, including comparisons of telithromycin (the first ketolide to undergo clinical development and be approved by the Food and Drug Administration) with other agents, a longitudinal global surveillance study--Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin (PROTEKT)--was launched in 1999. A US component of this study was initiated in 2000, and results from the first respiratory infection tracking season (2000-2001) are discussed in this article. Providing resistance ...Continue Reading

Citations

Jun 21, 2005·International Journal of Antimicrobial Agents·S SimoensW E Peetermans
Aug 14, 2013·Current Opinion in Microbiology·Roya Zoraghi, Neil E Reiner
Oct 3, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Martin J Burton, Richard M Rosenfeld
Oct 3, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John UpchurchRoger Echols

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