Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment

Neurochemistry International
Riina HäidkindJaanus Harro

Abstract

The present study aimed at characterizing the effect of partial 5-HT denervation by parachloroamphetamine (PCA), a 5-HT selective neurotoxin, on forced swimming behaviour and monoamine levels in several rat brain regions. PCA was administered intraperitoneally in two independent experiments in doses of 2, 4 and 6 mg/kg and in doses 1, 2, 4 mg/kg, respectively. PCA (2 mg/kg) reduced immobility in the forced swimming test in the Experiment 1 and according to Experiment 2 this is explained by increased swimming time. Dose-dependent reductions in 5-HT and 5-HIAA levels were found in all brain regions studied, and the maximal effects were of a similar magnitude. In septum, the effect of PCA took more time to develop. The effects of the lowest dose of PCA suggest that the neurotoxin affects not only the dorsal raphe projection areas but also the fine axons which arise from the median raphe. alpha2-Adrenoceptors and beta-adrenoceptors in cerebral cortex were not affected by the PCA treatment. Binding affinity of the 5-HT(1A) receptors was higher after all doses of PCA. On the second exposure to the forced swimming the time spent in swimming was found to be negatively and the time spent in immobile posture positively correlated with se...Continue Reading

Citations

Jul 27, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Margus KanarikJaanus Harro
Mar 8, 2017·Clinical and Experimental Pharmacology & Physiology·Keng-Fan LiuWen-Huang Peng
Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun-Jong JangDuck-Joo Rhie
Dec 19, 2018·Cell and Tissue Research·Jaanus Harro
Sep 11, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Margus TõnissaarJaanus Harro

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