PMID: 8938552Nov 1, 1996Paper

Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction

Journal of Hepatology
L RichterH Krell

Abstract

The pathophysiological role of leukotrienes in liver disease is not well understood. Redistribution or enhanced formation in cholestatic states may result in increased hepatic concentrations that are expected to contribute to liver injury. To disclose the potential role of cysteinyl-leukotrienes in chronic liver diseases, we studied biliary and urinary secretion in the model situation of relief of bile duct obstruction. Concentrations of cysteinyl-leukotrienes were determined in bile and urine of patients with extrahepatic biliary obstruction in the course of therapeutic decompression by endoscopic or transhepatic techniques. Leukotrienes were measured by radioimmunoassay after HPLC separation. Concentrations of bile acids in bile and serum were measured for comparison. Bile collected 2 h after decompression contained high concentrations of leukotrienes (57.5 +/- 22 microM). Biliary secretion decreased over 24 h reaching equilibrium values after 48-72 h (2.8 +/- 1.7 mM and 6.4 +/- 6.6 microM, respectively). Total bile acid concentration in serum followed a similar time course. In contrast, biliary bile acid concentration showed high interindividual variations. Bile contained all leukotriene C4, D4, E4 and NAc-LTE4, but LTC4 was...Continue Reading

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Citations

Aug 7, 1999·Clinical Reviews in Allergy & Immunology·J Y Westcott
Nov 7, 2006·Pediatric Surgery International·Savaş DemirbilekNilufer Ozatay
Oct 26, 2002·Journal of Hepatology·Gianluigi VendemialeEmanuele Altomare
Nov 25, 2003·Prostaglandins & Other Lipid Mediators·Ramin Farzaneh-Far, Kevin Moore
Dec 2, 2008·Prostaglandins & Other Lipid Mediators·Magdalena CuciureanuMihai Nechifor
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Qu LiuXue-Jun Sun
Feb 4, 2003·Journal of Pineal Research·Yoshiji OhtaTeruaki Kishikawa

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