Increased bilirubin levels in de novo Parkinson's disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Marcello MocciaCarmine Vitale

Abstract

Oxidative stress is a central pathogenic mechanism of Parkinson's disease (PD), and the heme oxygenase (HO) bilirubin pathway is one of the main mammalian antioxidative defences. Indeed, there is growing evidence of HO-bilirubin upregulation from early phases of PD. Our aim was to investigate bilirubin as a possible biomarker of PD diagnosis and progression. A cross-sectional case-control study was performed to evaluate differences in bilirubin levels between newly diagnosed, drug-naïve PD subjects and controls. Afterwards, PD subjects were included in a 2-year longitudinal study to evaluate disease progression in relation to baseline bilirubin levels. Seventy-five de novo PD subjects were selected and matched with 75 controls by propensity score. Analysis of variance showed higher bilirubin levels in PD patients compared with controls (P < 0.001). Linear regression analysis failed to show a relationship between bilirubin and Unified Parkinson's Disease Rating Scale (UPDRS) part III (P = 0.283) at baseline evaluation. At 2-year follow-up, indirect relationships between bilirubin levels and UPDRS part III (P = 0.028) and between bilirubin levels and levodopa-equivalent daily dosage (P = 0.012) were found. Parkinson's disease sub...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Apr 1, 1997·Italian Journal of Neurological Sciences·G SciglianoT Caraceni
Mar 26, 1998·Experimental Neurology·H M SchipperE G Stopa
Oct 24, 2002·Brain Research·Giovanni ScapagniniSebastiano Cavallaro
Mar 15, 2006·International Journal of Geriatric Psychiatry·Tae-Suk KimChang-Uk Lee
Aug 22, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K Ray Chaudhuri, P Martinez-Martin
May 22, 2009·Journal of Neurochemistry·Hyman M SchipperDavid Zeligman
Feb 16, 2010·Journal of Neuroscience Research·Noriyuki YamamotoAkinori Akaike
Oct 6, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Martin KöllenspergerUNKNOWN EMSA-SG
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Aug 2, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F PengX Zhong
Jan 30, 2013·Neurology·Melissa J ArmstrongWilliam J Weiner
Nov 22, 2013·The New England Journal of Medicine·Jon F Watchko, Claudio Tiribelli
Aug 12, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MocciaM T Pellecchia
Oct 14, 2014·Frontiers in Cellular Neuroscience·Pedro AyusoElena García-Martín

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Citations

Jun 12, 2016·Cell Biochemistry and Biophysics·Marcello MocciaCarmine Vitale
Nov 25, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Sep 7, 2019·Clinical Nuclear Medicine·Dong Yun LeeJae Seung Kim
Nov 20, 2016·Bioanalysis·Marcia Cristina Teixeira Dos SantosAndre Nogueira da Costa
May 28, 2020·International Journal of Molecular Sciences·Mark F McCarty, Aaron Lerner
Jul 30, 2019·Cell Chemical Biology·Chirag VasavdaSolomon H Snyder
Jul 3, 2021·International Journal of Molecular Sciences·Sri JayantiSilvia Gazzin

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