Increased biomagnetic activity in the ventral pathway in mild cognitive impairment

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Fernando MaestúTomás Ortiz

Abstract

Mild cognitive impairment (MCI) patients represent an intermediary state between healthy aging and dementia. MCI activation profiles, recorded during a memory task, have been studied either through high spatial resolution or high temporal resolution techniques. However, little is known about the benefit of combining both dimensions. Here, we investigate, by means of magnetoencephalography (MEG), whether spatio-temporal profiles of neuromagnetic activity could differentiate between MCI and age-matched elderly participants. Taking the advantage of the high temporal resolution and good spatial resolution of MEG, neuromagnetic activity from 15 elderly MCI patients and 20 age-matched controls was recorded during the performance of a modified version of the Sternberg paradigm. Behavioral performance was similar in both groups. A between group analysis revealed that MCI patients showed bilateral higher activity in the ventral pathway, in both the target and the non-target stimuli. A within-group analysis of the target stimuli, indicates a lack of asymmetry through all late latency windows in both groups. MCI patients showed a compensatory mechanism represented by an increased bilateral activity of the ventral pathway in order to achie...Continue Reading

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Citations

Mar 31, 2012·Brain Connectivity·Ricardo BajoFernando Maestu
May 28, 2010·Alzheimer Disease and Associated Disorders·Alberto FernándezTomás Ortiz
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Fernando MaestúAngel Nevado
Nov 28, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Sara AurtenetxeFernando Maestú
Mar 5, 2016·Behavioural Brain Research·Juan P Amezquita-SanchezHojjat Adeli
May 12, 2009·Neuroscience Letters·Elena SolesioFernando Maestú
Jan 11, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mehran AhmadlouHojjat Adeli
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Marie-Pierre DeiberPanteleimon Giannakopoulos
Sep 10, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fernando MaestuAngel Nevado
Oct 30, 2016·Frontiers in Neuroscience·Sara AurtenetxeFernando Maestú
Jan 11, 2018·The Proceedings of the Nutrition Society·Katie MooreHelene McNulty
Feb 23, 2019·Frontiers in Human Neuroscience·Fernando MaestúPaul E Schulz
Apr 28, 2020·Neuroimaging Clinics of North America·Fernando Maestú, Alberto Fernández

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