Increased blood-brain permeability with hyperosmolar mannitol increases cerebral O2 consumption and O2 supply/consumption heterogeneity

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
O Z ChiH R Weiss

Abstract

This study was performed to evaluate whether increasing the permeability of the blood-brain barrier by unilateral intracarotid injection of hyperosmolar mannitol would alter O2 consumption and the O2 supply/consumption balance in the ipsilateral cortex. Rats were anesthetized with 1.4% isoflurane using mechanical ventilation. Retrograde catheterization of a unilateral external carotid artery was performed to administer 25% mannitol at a rate of 0.25 ml/kg/s for 30 s. The blood-brain barrier transfer coefficient (K(i) of 14C-alpha aminoisobutyric acid was measured in one group (N = 7) after administering mannitol. Regional cerebral blood flow (rCBF), regional arterial and venous O2 saturation and O2 consumption were measured in another group using a 14C-iodoantipyrine autoradiographic technique and microspectrophotometry (N = 7). Vital signs were similar before and after administering mannitol. K(i) was significantly higher in the ipsilateral cortex (IC) (22.3 +/- 8.4 microliters/g/min) than in the contralateral cortex (CC) (4.4 +/-1.1). rCBF was similar between the IC (105 +/- 21 ml/g/min) and the CC (93 +/- 20). Venous O2 saturation was lower in the IC (43 +/- 7%) than in the CC (55 +/- 4%). The coefficient of variation (100 x...Continue Reading

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Citations

Jan 30, 2013·Journal of the Neurological Sciences·Oak Z ChiHarvey R Weiss
Dec 26, 2006·Experimental Neurology·Oak Z ChiHarvey R Weiss
Oct 9, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Oak Z ChiHarvey R Weiss
Nov 20, 2016·Neurosurgery·Ian LeeConstantinos G Hadjipanayis
Oct 20, 2015·Journal of Neurology·B Milojkovic KerklaanD Brandsma
Feb 5, 2019·ACS Chemical Neuroscience·Ruby Gupta, Deepika Sharma

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Methods Mentioned

BETA
light scattering

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