Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer's disease.

Scientific Reports
Nobuyuki KobayashiKazuhiro Kondo

Abstract

Early diagnosis of dementia including Alzheimer's disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is associated with neurodegeneration through a comparison of AD, AD with cardiovascular disease (CVD), and vascular dementia (VaD). We measured blood COASY methylation levels in normal controls (NCs) (n = 200), and individuals with aMCI (n = 22), AD (n = 151), and VaD (n = 21). Compared with NCs, they were significantly higher in individuals with aMCI and AD. Further, they were significantly higher in AD patients without cardiovascular diseases compared to AD patients with them. These findings suggest that COASY methylation levels may be related to neurodegeneration in AD.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Dec 14, 2002·Annals of the New York Academy of Sciences·Amos D Korczyn
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Jan 5, 2012·Nature Reviews. Genetics·Robert Feil, Mario F Fraga
Apr 5, 2012·Current Gerontology and Geriatrics Research·Joseph H LeeNicole Schupf
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Oct 22, 2013·Genome Biology·Steve Horvath
Dec 24, 2013·American Journal of Human Genetics·Sabrina DusiValeria Tiranti
Nov 26, 2015·Lancet·John T O'Brien, Alan Thomas
Mar 31, 2016·EMBO Molecular Medicine·Dennis J Selkoe, John Hardy
Apr 23, 2016·Journal of Women & Aging·Jay Geronimo RonquilloWilliam T Lester
Nov 12, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter D FransquetJoanne Ryan
Dec 11, 2017·Methods in Molecular Biology·Dianna Hussmann, Lise Lotte Hansen
Mar 14, 2018·Nature Communications·Chao-Chieh LinJen-Tsan Chi
Dec 12, 2018·Journal of Alzheimer's Disease : JAD·André de Macêdo Medeiros, Regina Helena Silva
Jan 17, 2020·Psychiatry and Clinical Neurosciences·Hisashi KidaHidehito Niimura

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Citations

May 11, 2021·Journal of Alzheimer's Disease : JAD·Nobuyuki KobayashiKazuhiro Kondo

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Methods Mentioned

BETA
PCR
Genotyping
Methylation

Software Mentioned

Prism
Sequence Detection
GraphPad
SPSS Statistics

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