Nov 2, 2018

Near-infrared light increases functional connectivity with a non-thermal mechanism

BioRxiv : the Preprint Server for Biology
Greg M DmochowskiJacek Dmochowski

Abstract

Although techniques for non-invasive brain stimulation are under intense investigation, an approach that has received limited attention is transcranial photobiomodulation (tPBM), the delivery of near-infrared light to the brain with a laser directed at the scalp. Here we employed functional magnetic resonance imaging (fMRI) to measure the Blood-Oxygenation-Level Dependent (BOLD) signal in n=20 healthy humans while concurrently stimulating their right frontal pole with a near-infrared laser. We failed to detect an evoked BOLD response at illumination. However, functional connectivity with the illuminated region increased by an average of 10% during stimulation, with some connections strengthening by as much as 40%. 23% of connections with the illuminated region experienced a significant acute increase, with the time course of connectivity exhibiting a sharp rise at illumination onset. Brain-wide connectivity increases were also observed, with connections in the stimulated hemisphere showing a significantly larger increase than those in the non-stimulated hemisphere. We subsequently employed MR Thermometry to measure brain temperature during tPBM (separate cohort, n=20), and found no significant temperature differences between ac...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Alveolar Ventilation Function
Forehead
Prefrontal Cortex
Magnetic Resonance Imaging
Blood Vessel
Neurological System Process
Brain
Cell Respiration
Blood Flow

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