Increased blood hemoglobin attenuates splanchnic vasodilation in portal-hypertensive rats by nitric oxide inactivation

Gastroenterology
M CasadevallJ Rodés

Abstract

Nitric oxide, which is quenched by hemoglobin, has been implicated in the pathogenesis of portal hypertension. The aim of this study was to investigate the effects of increasing blood hemoglobin concentration by erythropoietin treatment on the gastrointestinal vasodilation associated with portal hypertension. Portal-hypertensive and sham-operated rats treated with erythropoietin were studied 2 weeks after surgery. Hemodynamic and rheological parameters were measured in baseline conditions and after N(G)-nitro-L-arginine methyl ester (L-NAME) or sodium nitroprusside treatment. In portal-hypertensive rats, erythropoietin attenuated the increase in gastric mucosal and superior mesenteric artery blood flows and the decrease in arterial blood pressure and splanchnic vascular resistances. Those parameters were not affected by erythropoietin in sham-operated rats. A direct vascular effect of erythropoietin was ruled out by the lack of changes in blood pressure or mesenteric blood flow after intravenous erythropoietin administration and by a similar in vitro relaxation to acetylcholine in mesenteric artery rings. In portal-hypertensive rats, erythropoietin blunted the blood pressure response to sodium nitroprusside and attenuated the g...Continue Reading

Citations

May 17, 2001·Journal of Gastroenterology and Hepatology·K TsugawaK Sugimachi
Aug 8, 2006·Journal of Cardiovascular Pharmacology·Sen CuiYasutaka Kurata
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HeinemannR E Stauber
Apr 20, 1999·Journal of Gastroenterology and Hepatology·W C LeeS D Lee
Oct 20, 2000·American Journal of Veterinary Research·L M HoweS Wilkie
Jun 6, 2007·Hypertension·Mary S LeeJong Y Lee
Dec 6, 2007·Journal of Clinical Gastroenterology·Reiner Wiest
Dec 1, 2000·Scandinavian Journal of Gastroenterology·K TsugawaK Sugimachi
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiner Wiest, Roberto J Groszmann
Jul 2, 2011·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yoshihito KatoKyoichi Mizuno
Oct 2, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marek SaracynZofia Wańkowicz
May 29, 1998·American Journal of Respiratory and Critical Care Medicine·C DefouilloyS Adnot
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathD K Rorie
Feb 16, 2005·Annual Review of Physiology·David J Singel, Jonathan S Stamler
Jul 4, 2009·World Journal of Gastroenterology : WJG·Mohannad Abu-Hilal, Jayant Tawaker
Aug 23, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yasumi KatsutaTeruo Takano

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