Increased blood plasma concentrations of TGF-beta isoforms after treatment with intravenous immunoglobulins (i.v.IG) in patients with multiple sclerosis

Journal of Neuroimmunology
Dirk ReinholdMichael Sailer

Abstract

To assess whether TGF-beta isoforms are significantly increased after intravenous immunoglobulin (i.v.IG) infusion in the plasma of patients with multiple sclerosis (MS), 19 patients with clinically definite MS were enrolled in a double blind placebo controlled i.v.IG study. TGF-beta1, TGF-beta2, TGF-beta3 plasma concentrations were measured prior and directly after i.v.IG infusions by specific ELISA. Compared to the placebo group, we found a significant increase in the plasma levels of all three TGF-beta isoforms in patients treated with i.v.IG. The significantly increased TGF-beta plasma concentrations in treated patients suggest an additional, immediate mechanism of action that may accompany the molecular effects of i.v.IG therapy in MS. The variable amount of the potent anti-inflammatory TGF-beta isoforms within the i.v.IG preparations may exert a differentiated view regarding the manifold indications of i.v.IG therapy.

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Citations

Jun 25, 2013·Trends in Pharmacological Sciences·Mathias ButtmannHans-Peter Hartung
Sep 30, 2015·Journal of Proteome Research·Amit KumarMichael J Betenbaugh
Oct 4, 2007·Annals of the New York Academy of Sciences·Michael Sticherling, Henning Trawinski
Jan 30, 2015·Frontiers in Immunology·Andrea MatucciAlessandra Vultaggio
Sep 10, 2010·Journal of Tissue Engineering and Regenerative Medicine·Beili ZhuC Mauli Agrawal
Feb 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·H F PetereitO R Hommes
Sep 3, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anke RissmannDirk Reinhold
Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G N BisagaA E Popov

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