Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin escape

American Journal of Physiology. Renal Physiology
Jian SongCarolyn A Ecelbarger

Abstract

The syndrome of inappropriate antidiuretic hormone (SIADH) is associated with water retention and hyponatremia. The kidney adapts via a transient natriuresis and persistent diuresis, i.e., vasopressin escape. Previously, we showed an increase in the whole kidney abundance of aldosterone-sensitive proteins, the alpha- and gamma (70-kDa-band)-subunits of the epithelial Na(+) channel (ENaC), and the thiazide-sensitive Na-Cl cotransporter (NCC) in our rat model of SIADH. Here we examine mean arterial pressure via radiotelemetry, aldosterone activity, and cortical vs. medullary ENaC subunit and 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2) protein abundances in escape. Eighteen male Sprague-Dawley rats (300 g) were sham operated (n = 6) or infused with desmopressin (dDAVP; n = 12, a V(2) receptor-selective analog of AVP). After 4 days, one-half of the rats receiving dDAVP were switched to a liquid diet, i.e., water loaded (WL) for 5-7 additional days. The WL rats had a sustained increase in urine volume and blood pressure (122 vs. 104 mmHg, P < 0.03, at 7 days). Urine and plasma aldosterone levels were increased in the WL group to 844 and 1,658% of the dDAVP group, respectively. NCC and alpha- and gamma-ENaC (70-kDa band...Continue Reading

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Citations

Jan 5, 2005·Pflügers Archiv : European journal of physiology·Bonnie L Blazer-YostMichael Gekle
May 5, 2006·Current Hypertension Reports·Carolyn A Ecelbarger, Swasti Tiwari
Apr 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Swasti TiwariCarolyn M A Ecelbarger
Nov 6, 2009·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn M Ecelbarger
Feb 6, 2009·American Journal of Physiology. Renal Physiology·Shahla RiaziC M Ecelbarger
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Oct 25, 2013·American Journal of Physiology. Renal Physiology·Marleen L A KortenoevenPeter M T Deen

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