Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats.

Hypertension
Masashi MukohdaHiroshi Ozaki

Abstract

The lymphatic system is involved in the pathogenesis of edema, inflammation, and cancer metastasis. Because lymph vessels control fluid electrolytes and volume balance, changes in lymphatic activity can be expected to alter systemic blood pressure. This study examined possible changes in lymphatic contractile properties in spontaneously hypertensive rats (SHR). Thoracic ducts isolated from 10- to 12-week-old SHR exhibited either decreased acetylcholine-induced endothelium-dependent relaxation or sodium nitroprusside-induced endothelium-independent relaxation compared with age-matched Wister-Kyoto rats. The impairment in acetylcholine responsiveness was more pronounced than sodium nitroprusside responsiveness. N-Nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor blunted acetylcholine-induced relaxation in Wister-Kyoto rats, indicating an involvement of endothelial nitric oxide production. Endothelial dysfunction in lymph vessels of SHR was attenuated by tempol (a superoxide dismutase mimetic), apocynin, or VAS-2870 (NADPH oxidase inhibitors). Consistent with these observations, nitrotyrosine levels were significantly elevated in SHR, indicative of increased oxidative stress. In addition, protein expression of NADPH...Continue Reading

References

Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N AzumaB E Sumpio
Oct 17, 2002·Nitric Oxide : Biology and Chemistry·Huige LiUlrich Förstermann
Feb 1, 2003·The Journal of Biological Chemistry·Jian-Mei Li, Ajay M Shah
Jan 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·F A DeLanoG W Schmid-Schönbein
Feb 12, 2005·Antioxidants & Redox Signaling·J D Van BuulP L Hordijk
Jun 17, 2006·The Journal of Clinical Investigation·Pham My-Chan DangJamel El-Benna
Feb 13, 2007·Cancer Cell·Ignacio DoladoAngel R Nebreda
May 8, 2007·Biochimica Et Biophysica Acta·Ana Cuenda, Simon Rousseau
Jun 9, 2007·The Journal of Clinical Investigation·Dmitriy N AtochinPaul L Huang
Dec 20, 2007·American Journal of Hypertension·Junhui ZhenXin J Zhou
Sep 22, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yang-Ming YangDong Sun
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Bernard Lassègue, Kathy K Griendling
Apr 7, 2010·Biochimie·Gopi Krishna KolluruSuvro Chatterjee
Sep 14, 2012·Journal of Pharmacological Sciences·Masashi MukohdaHideyuki Yamawaki
Dec 5, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Cristina T KeslerTimothy P Padera
Mar 5, 2014·The Journal of Clinical Investigation·Pascal BrouillardMiikka Vikkula
Mar 5, 2014·The Journal of Clinical Investigation·Honsoul KimGou Young Koh
Apr 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Taina VuorioSeppo Ylä-Herttuala
Jul 30, 2014·Trends in Endocrinology and Metabolism : TEM·Grant R Drummond, Christopher G Sobey
Nov 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Masashi MukohdaCurt D Sigmund
Mar 23, 2018·Nature Reviews. Disease Primers·Suzanne OparilPaul K Whelton
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Aug 4, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi UmemuraNobuhito Hirawa

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Citations

Aug 6, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bing WangRuijuan Xiu
Aug 15, 2021·The Journal of Pharmacology and Experimental Therapeutics·Masashi MukohdaHiroshi Ozaki

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