PMID: 7334088Jan 1, 1981Paper

Increased blood viscosity in patients with Legg-Perthes disease: a preliminary report

Journal of Pediatric Orthopedics
R G Kleinman, E E Bleck

Abstract

Based on studies by others, it appears that Legg-Perthes disease is an avascular necrosis of the femoral head due to occlusion of the blood supply. In an effort to delineate the pathogenesis of the disorder, we determined blood viscosity and percent platelet aggregation in 22 patients with Legg-Perthes disease and 21 control patients. Statistically significant higher blood viscosities were found in our patients with Legg-Perthes when compared with normals. No difference was found in the platelet aggregation studies. In accordance with Poiseuille's law, we propose that increased blood viscosity in patients with the affliction could lead to a diminution in blood flow to the capital femoral epiphysis, ultimately resulting in osteonecrosis and symptomatic manifestations of the disease.

Citations

Jan 1, 1984·International Orthopaedics·P J Klisić
Jun 29, 2007·Archives of Orthopaedic and Trauma Surgery·A Mumtaz AlpaslanMuharrem Yazici
Jan 1, 2011·ISRN Orthopedics·Randall T Loder, Elaine N Skopelja
Jan 4, 2017·Injury·Enrique Guerado, Enrique Caso
Jun 8, 2004·Southern Medical Journal·Brian T Carney, Christin L Minter
Jan 9, 2001·American Journal of Medical Genetics·D ElsteinA Zimran
Nov 20, 1998·Journal of Pediatric Orthopedics·R M KayD K Kehl
Mar 25, 2006·Journal of Pediatric Orthopedics·J S MehtaJ B M Winter
Dec 16, 2004·Journal of Pediatric Orthopedics. Part B·J Eric GordonScott J Luhmann
May 12, 2001·Clinical Orthopaedics and Related Research·T AtsumiY Hiranuma

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