Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Bartłomiej PalecznyPiotr Ponikowski

Abstract

Increased peripheral chemosensitivity (PChS) has been proposed as mechanism underlying obesity-related sympathoactivation, with insulin and/or leptin as possible mediators. However, human data on PChS in obesity are scarce. Therefore, we explored this issue in a sample of 41 healthy men aged 30-59 years, divided according to body fat percentage (fat %) into two groups: <25 and ≥25 %. PChS was assessed using transient hypoxia method [respiratory (PChS-MV), heart rate (PChS-HR), and blood pressure (PChS-SBP) responses were calculated]. Baroreflex sensitivity (BRS-Seq) was assessed using sequence method. Fasting plasma insulin and leptin levels were measured. Homeostatic model assessment (HOMA) was used to assess insulin sensitivity/resistance. Individuals with ≥25 % body fat demonstrated increased PChS-SBP (p < 0.01), but unchanged PChS-MV and PChS-HR (both p > 0.4). PChS-SBP was related positively with anthropometric characteristics (e.g. waist circumference, fat %), plasma insulin and HOMA (all p < 0.05), and negatively with BRS-Seq (p = 0.001), but not with plasma leptin (p = 0.27). In healthy men, overweight/obesity is accompanied by augmented blood pressure response from peripheral chemoreceptors, while respiratory and heart...Continue Reading

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Citations

Apr 8, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Isabelle Magalhães Guedes FreitasMateus Camaroti Laterza
Sep 27, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Parul Chaudhary, Ann M Schreihofer
Jan 16, 2019·International Journal of Environmental Research and Public Health·José Miguel Robles-RomeroCarlos Ruiz-Frutos
Mar 18, 2020·International Journal of Environmental Research and Public Health·Alena A NikanorovaSardana A Fedorova
Aug 7, 2020·International Journal of Molecular Sciences·Joana F SacramentoSilvia V Conde

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