Increased body mass index associated with autonomic dysfunction in Parkinson's disease

Parkinsonism & Related Disorders
Hitoshi MochizukiMasamitsu Nakazato

Abstract

The association between Parkinson's disease (PD) and body mass index (BMI) has not been established. In this study, we investigated the correlation between BMI and autonomic dysfunction in patients with PD. Clinical features, BMI, cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy and the coefficient of variation of the electrocardiographic R-R interval (CVRR) were analyzed in 124 patients with PD who were naïve to anti-parkinsonian drugs. BMI was negatively correlated with early heart-to-mediastinum ratio and CVRR in patients with PD, regardless of disease duration and severity. Autonomic dysfunction and BMI increase were associated with each other. Physicians should consider the possibility of autonomic dysfunction in PD patients with high BMI.

References

Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Feb 19, 2005·Endocrinology·Shuichi KodaMasamitsu Nakazato
Nov 22, 2011·Parkinsonism & Related Disorders·Marjolein A van der MarckMarten Munneke
Nov 7, 2013·PloS One·Guy H E J VijgenWouter D van Marken Lichtenbelt
Nov 23, 2013·Parkinsonism & Related Disorders·Jose-Alberto Palma, Horacio Kaufmann

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Citations

Jul 1, 2016·Acta Neurologica Scandinavica·T UmeharaH Oka
Mar 17, 2019·Aging Clinical and Experimental Research·Maria S PisciottaDavide L Vetrano
Oct 31, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qing WuMeizhen Liu

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