Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population

Kidney International
Quan-Lan Jasmine LewWoon Puay Koh

Abstract

The relationship between body mass index (BMI) and end-stage renal disease (ESRD) is confounded by co-morbidities associated with both conditions. Furthermore, the association at low range BMI is controversial. We studied this association in the Singapore Chinese Health Study, a population-based prospective cohort that recruited Singaporean Chinese men and women 45-74 years of age from 1993 to 1998. Self-reported weight, height, lifestyle factors, usual diet, and medical history were collected via an interviewer-administered questionnaire. Incident ESRD cases were identified via record linkage with the nationwide ESRD registry. The computed Cox proportional hazard regression was adjusted for potential risk factors. After an average follow-up of 15.5 years, 827 incident ESRD cases were identified. Compared with a normal BMI of 18.5 to under 23 kg/m2, the hazard ratios and (95% confidence intervals) of ESRD risk for BMIs under 18.5, 23 to under 27.5, and 27.5 kg/m2 or more were 0.54 (0.37-0.79), 1.40 (1.20-1.64) and 2.13 (1.74-2.59), respectively. This significantly trended, linear, dose-dependent association was only present among those with no history of diabetes, hypertension, coronary heart disease, and stroke at baseline, bu...Continue Reading

Citations

Nov 27, 2019·Journal of the American Heart Association·Ting-Ting GengWoon-Puay Koh
Oct 16, 2018·The American Journal of Clinical Nutrition·Ting-Yun LinSzu-Chun Hung
Jan 1, 2021·The American Journal of Clinical Nutrition·Ting-Ting GengWoon-Puay Koh
Mar 4, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K R D PintoV N Hirakata

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